Systematic evaluation of narrow‐sense validity of polygenic risk score for prostate cancer in a Chinese prostate biopsy cohort

• Published in: Clinical genetics Vol. 103; no. 6; pp. 636 - 643
• Main Authors: Wu, Yishuo, Ruan, Xiaohao, Gao, Peng, Da, Huang, Fang, Zujun, Xu, Danfeng, Jiang, Haowen, Ding, Qiang, Lin, Xiaoling, Lu, Daru, Na, Rong
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2023
• Subjects: benchmark; Biopsy; Calibration; East Asian People; Genetic diversity; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; polygenic risk score; Population studies; Prospective Studies; Prostate - pathology; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Risk assessment; Risk Assessment - methods; Risk Factors; Validity; biopsy; prostate cancer; validity; polygenic risk score; benchmark

The aim of this study was to assess the narrow‐sense validity of polygenic risk score (PRS) for prostate cancer (PCa) in a Chinese prostate biopsy cohort. We performed an observational prospective study with 2640 men who underwent prostate biopsy. Germline DNA samples were genotyped and PRS was calc...