Determination of serum and gingival crevicular fluid levels of omentin in healthy and rheumatoid arthritis subjects with and without periodontitis

• Published in: Oral diseases Vol. 30; no. 4; pp. 2645 - 2652
• Main Authors: Mohit, Jyothi, Ari, Geetha, Mahendra, Jaideep, Prakash, Prashanthi, Bedi, Muskan, Dave, Pavithra H., Logaranjani, Anitha, Namasivayam, Ambalavanan
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.05.2024
• Subjects: adipokines; Adult; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - metabolism; biomarkers; Case-Control Studies; Cytokines - analysis; Cytokines - blood; Cytokines - metabolism; Dental plaque; Dental Plaque Index; Female; GCF; Gingiva; Gingival Crevicular Fluid - chemistry; Gingival Crevicular Fluid - metabolism; Gingival index; GPI-Linked Proteins - analysis; GPI-Linked Proteins - blood; GPI-Linked Proteins - metabolism; Gum disease; Humans; Lectins - blood; Male; Medical diagnosis; Middle Aged; omentin; Periodontal Index; Periodontics; Periodontitis; Periodontitis - blood; Periodontitis - metabolism; Plaque index; Rheumatoid arthritis; serum; omentin; biomarkers; periodontitis; adipokines; GCF; serum; rheumatoid arthritis
• ISSN: 1354-523X; 1601-0825; 1601-0825
• DOI: 10.1111/odi.14695

Objective The aim of this study was to assess and correlate the serum and GCF levels of omentin with the periodontal status of rheumatoid arthritis (RA) patients with and without periodontitis. Methods Forty‐four patients were divided into four groups: group H: 11 systemically and periodontally healthy subjects; group P: 11 systemically healthy subjects with periodontitis; group RA: 11 periodontally healthy subjects with rheumatoid arthritis and group RA + P: 11 rheumatoid arthritis subjects with periodontitis. Periodontal parameters (plaque index, modified gingival index, probing depth, and clinical attachment level) were recorded and serum and GCF samples were collected for the estimation of omentin using ELISA. Results The mean value of plaque index, modified gingival index, probing depth, and clinical attachment level were significantly higher whereas serum and GCF omentin levels were found to be decreased in group IV when compared to the other groups. The significant correlation was found between the serum and GCF omentin levels with all the periodontal parameters. Conclusion The omentin level in serum and GCF was found to be lower in RA patients with periodontitis. It is also inversely correlated with the periodontal parameters. Thus, omentin can serve as a significant diagnostic and therapeutic tool in both periodontal and rheumatoid disease.