Where It’s at Really Matters: In Situ In Vivo Vascular Endothelial Growth Factor Spatially Correlates with Electron Paramagnetic Resonance pO2 Images in Tumors of Living Mice
Purpose Tumor microenvironments show remarkable tumor pO 2 heterogeneity, as seen in prior EPR pO 2 images (EPROI). pO 2 correlation with hypoxia response proteins is frustrated by large rapid pO 2 changes with position. Procedures To overcome this limitation, biopsies stereotactically located in th...
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| Published in | Molecular imaging and biology Vol. 13; no. 6; pp. 1107 - 1113 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer-Verlag
01.12.2011
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1536-1632 1860-2002 1860-2002 |
| DOI | 10.1007/s11307-010-0436-4 |
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| Abstract | Purpose
Tumor microenvironments show remarkable tumor pO
2
heterogeneity, as seen in prior EPR pO
2
images (EPROI). pO
2
correlation with hypoxia response proteins is frustrated by large rapid pO
2
changes with position.
Procedures
To overcome this limitation, biopsies stereotactically located in the EPROI were used to explore the relationship between vascular endothelial growth factor A (VEGF) concentrations in living mouse tumors and the local EPROI pO
2
.
Results
Quantitative ELISA VEGF concentrations correlated (
p
= 0.0068 to 0.019) with mean pO
2
, median pO
2
, and the fraction of voxels in the biopsy volume with pO
2
less than 3, 6, and 10 Torr.
Conclusions
This validates EPROI hypoxic fractions at the molecular level and provides a new paradigm for the assessment of the relationship,
in vivo
, between hypoxia and hypoxia response proteins. When translated to human subjects, this will enhance understanding of human tumor pathophysiology and cancer response to therapy. |
|---|---|
| AbstractList | Tumor microenvironments show remarkable tumor pO(2) heterogeneity, as seen in prior EPR pO(2) images (EPROI). pO(2) correlation with hypoxia response proteins is frustrated by large rapid pO(2) changes with position.PURPOSETumor microenvironments show remarkable tumor pO(2) heterogeneity, as seen in prior EPR pO(2) images (EPROI). pO(2) correlation with hypoxia response proteins is frustrated by large rapid pO(2) changes with position.To overcome this limitation, biopsies stereotactically located in the EPROI were used to explore the relationship between vascular endothelial growth factor A (VEGF) concentrations in living mouse tumors and the local EPROI pO(2).PROCEDURESTo overcome this limitation, biopsies stereotactically located in the EPROI were used to explore the relationship between vascular endothelial growth factor A (VEGF) concentrations in living mouse tumors and the local EPROI pO(2).Quantitative ELISA VEGF concentrations correlated (p = 0.0068 to 0.019) with mean pO(2), median pO(2), and the fraction of voxels in the biopsy volume with pO(2) less than 3, 6, and 10 Torr.RESULTSQuantitative ELISA VEGF concentrations correlated (p = 0.0068 to 0.019) with mean pO(2), median pO(2), and the fraction of voxels in the biopsy volume with pO(2) less than 3, 6, and 10 Torr.This validates EPROI hypoxic fractions at the molecular level and provides a new paradigm for the assessment of the relationship, in vivo, between hypoxia and hypoxia response proteins. When translated to human subjects, this will enhance understanding of human tumor pathophysiology and cancer response to therapy.CONCLUSIONSThis validates EPROI hypoxic fractions at the molecular level and provides a new paradigm for the assessment of the relationship, in vivo, between hypoxia and hypoxia response proteins. When translated to human subjects, this will enhance understanding of human tumor pathophysiology and cancer response to therapy. Tumor microenvironments show remarkable tumor pO(2) heterogeneity, as seen in prior EPR pO(2) images (EPROI). pO(2) correlation with hypoxia response proteins is frustrated by large rapid pO(2) changes with position. To overcome this limitation, biopsies stereotactically located in the EPROI were used to explore the relationship between vascular endothelial growth factor A (VEGF) concentrations in living mouse tumors and the local EPROI pO(2). Quantitative ELISA VEGF concentrations correlated (p = 0.0068 to 0.019) with mean pO(2), median pO(2), and the fraction of voxels in the biopsy volume with pO(2) less than 3, 6, and 10 Torr. This validates EPROI hypoxic fractions at the molecular level and provides a new paradigm for the assessment of the relationship, in vivo, between hypoxia and hypoxia response proteins. When translated to human subjects, this will enhance understanding of human tumor pathophysiology and cancer response to therapy. Tumor microenvironments show remarkable tumor pO2 heterogeneity, as seen in prior EPR pO2 images (EPROI). pO2 correlation with hypoxia response proteins is frustrated by large rapid pO2 changes with position. To overcome this limitation, biopsies stereotactically located in the EPROI were used to explore the relationship between vascular endothelial growth factor A (VEGF) concentrations in living mouse tumors and the local EPROI pO2. Quantitative ELISA VEGF concentrations correlated (p=0.0068 to 0.019) with mean pO2, median pO2, and the fraction of voxels in the biopsy volume with pO2 less than 3, 6, and 10 Torr. This validates EPROI hypoxic fractions at the molecular level and provides a new paradigm for the assessment of the relationship, in vivo, between hypoxia and hypoxia response proteins. When translated to human subjects, this will enhance understanding of human tumor pathophysiology and cancer response to therapy.[PUBLICATION ABSTRACT] Purpose Tumor microenvironments show remarkable tumor pO 2 heterogeneity, as seen in prior EPR pO 2 images (EPROI). pO 2 correlation with hypoxia response proteins is frustrated by large rapid pO 2 changes with position. Procedures To overcome this limitation, biopsies stereotactically located in the EPROI were used to explore the relationship between vascular endothelial growth factor A (VEGF) concentrations in living mouse tumors and the local EPROI pO 2 . Results Quantitative ELISA VEGF concentrations correlated ( p = 0.0068 to 0.019) with mean pO 2 , median pO 2 , and the fraction of voxels in the biopsy volume with pO 2 less than 3, 6, and 10 Torr. Conclusions This validates EPROI hypoxic fractions at the molecular level and provides a new paradigm for the assessment of the relationship, in vivo , between hypoxia and hypoxia response proteins. When translated to human subjects, this will enhance understanding of human tumor pathophysiology and cancer response to therapy. |
| Author | Weichselbaum, Ralph R. Halpern, Howard J. Haney, Chad R. Ahn, Kang-Hyun Barth, Eugene D. Pelizzari, Charles A. Hleihel, Danielle Elas, Martyna Epel, Boris |
| Author_xml | – sequence: 1 givenname: Martyna surname: Elas fullname: Elas, Martyna organization: Department of Radiation and Cellular Oncology, University of Chicago, Center for EPR Imaging In Vivo Physiology, University of Chicago, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University – sequence: 2 givenname: Danielle surname: Hleihel fullname: Hleihel, Danielle organization: Department of Radiation and Cellular Oncology, University of Chicago, Center for EPR Imaging In Vivo Physiology, University of Chicago – sequence: 3 givenname: Eugene D. surname: Barth fullname: Barth, Eugene D. organization: Department of Radiation and Cellular Oncology, University of Chicago, Center for EPR Imaging In Vivo Physiology, University of Chicago – sequence: 4 givenname: Chad R. surname: Haney fullname: Haney, Chad R. organization: Department of Radiology, University of Chicago – sequence: 5 givenname: Kang-Hyun surname: Ahn fullname: Ahn, Kang-Hyun organization: Department of Radiation and Cellular Oncology, University of Chicago, Center for EPR Imaging In Vivo Physiology, University of Chicago – sequence: 6 givenname: Charles A. surname: Pelizzari fullname: Pelizzari, Charles A. organization: Department of Radiation and Cellular Oncology, University of Chicago – sequence: 7 givenname: Boris surname: Epel fullname: Epel, Boris organization: Department of Radiation and Cellular Oncology, University of Chicago, Center for EPR Imaging In Vivo Physiology, University of Chicago – sequence: 8 givenname: Ralph R. surname: Weichselbaum fullname: Weichselbaum, Ralph R. organization: Department of Radiation and Cellular Oncology, University of Chicago – sequence: 9 givenname: Howard J. surname: Halpern fullname: Halpern, Howard J. email: h-halpern@uchicago.edu organization: Department of Radiation and Cellular Oncology, University of Chicago, Center for EPR Imaging In Vivo Physiology, University of Chicago, MC1105, AMB ESB05a, University of Chicago Medical Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20960236$$D View this record in MEDLINE/PubMed |
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Tumor microenvironments show remarkable tumor pO
2
heterogeneity, as seen in prior EPR pO
2
images (EPROI). pO
2
correlation with hypoxia response... Tumor microenvironments show remarkable tumor pO(2) heterogeneity, as seen in prior EPR pO(2) images (EPROI). pO(2) correlation with hypoxia response proteins... Tumor microenvironments show remarkable tumor pO2 heterogeneity, as seen in prior EPR pO2 images (EPROI). pO2 correlation with hypoxia response proteins is... |
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| SubjectTerms | Animals Cell Hypoxia Diagnostic Imaging - methods Electron Spin Resonance Spectroscopy - methods Humans Imaging Medicine Medicine & Public Health Mice Neoplasms - metabolism Neoplasms - pathology Oxygen - metabolism Partial Pressure Radiology Research Article Vascular Endothelial Growth Factor A - metabolism |
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| Title | Where It’s at Really Matters: In Situ In Vivo Vascular Endothelial Growth Factor Spatially Correlates with Electron Paramagnetic Resonance pO2 Images in Tumors of Living Mice |
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