Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver

• Published in: NMR in biomedicine Vol. 38; no. 4; pp. e70014 - n/a
• Main Authors: Gursan, Ayhan, Graaf, Robin A., Thomas, Monique A., Prompers, Jeanine J., De Feyter, Henk M.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.04.2025
• Subjects: Animals; Data acquisition; de novo lipogenesis; Deuteration; Deuterium; deuterium magnetic resonance spectroscopy; Drinking water; Feasibility; Labeling; lipid metabolism; Lipids; Lipogenesis; Lipogenesis - physiology; Liver; Liver - metabolism; Low density lipoprotein; Magnetic Resonance Spectroscopy - methods; Male; Metabolic disorders; NMR; Nuclear magnetic resonance; Pathogenesis; Rats; Rats, Sprague-Dawley; Triglycerides; deuterium magnetic resonance spectroscopy; de novo lipogenesis; liver; nuclear magnetic resonance; lipid metabolism

ABSTRACT Hepatic de novo lipogenesis (DNL) plays a key role in the pathogenesis of several metabolic diseases that affect the liver. In humans, the detection of deuterium (2H) in triglycerides from very low density lipoprotein collected from blood after administration of deuterated water (D2O) is co...