Emerging roles of the renin‐angiotensin system in select oral diseases

• Published in: Oral diseases Vol. 31; no. 1; pp. 39 - 49
• Main Authors: Liu, Yixing, Liu, Zhe
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.01.2025
• Subjects: ACE2; ageusia; Alveolar bone; Angiogenesis; Angiotensin; Angiotensin II; Angiotensin-Converting Enzyme 2; Bone loss; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - physiopathology; Cell proliferation; Dysgeusia - metabolism; Dysgeusia - physiopathology; Fibrosis; Gum disease; Humans; Invasiveness; Mouth Diseases - metabolism; Mouth Diseases - physiopathology; Mouth Neoplasms - metabolism; Mouth Neoplasms - physiopathology; Oral carcinoma; Oral diseases; oral squamous cell carcinoma; oral submucous fibrosis; Oral Submucous Fibrosis - metabolism; Oral Submucous Fibrosis - physiopathology; Osteoclastogenesis; Periodontitis; Periodontitis - metabolism; Periodontitis - physiopathology; Renal cell carcinoma; Renal function; Renin; Renin-Angiotensin System - physiology; renin‐angiotensin system; Squamous cell carcinoma; Squamous cells; Sweet taste; Taste disorders; ageusia; oral submucous fibrosis; oral squamous cell carcinoma; renin‐angiotensin system; periodontitis

Objectives The renin‐angiotensin system (RAS) plays essential roles in cardiovascular and renal function regulation. Recent studies have shown that the RAS components are widely expressed in oral tissues, but their roles in oral diseases remain underexplored. This review aims to summarize the effect...