Implications of the non‐neuronal cholinergic system for therapeutic interventions of inflammatory skin diseases

• Published in: Experimental dermatology Vol. 33; no. 10; pp. e15181 - n/a
• Main Authors: Qu, Hui‐Qi, Kao, Charlly, Hakonarson, Hakon
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.10.2024
• Subjects: Acetylcholine; Acetylcholine - metabolism; Acetylcholine receptors (muscarinic); Acetylcholinesterase; Acne; Animals; Atopic dermatitis; Botulinum toxin; Bullous diseases; Cholinergic transmission; Cholinesterase Inhibitors - therapeutic use; Dermatitis - drug therapy; Dermatitis - metabolism; dermatology; Endothelial cells; Humans; inflammation; Inflammation - metabolism; Keratinocytes; Macrophages; Medical innovations; Nervous system; Non-Neuronal Cholinergic System; non‐neuronal cholinergic systems; Psoriasis; Rosacea; Skin - metabolism; skin cells; Skin diseases; Skin Diseases - drug therapy; Skin Diseases - metabolism; Therapeutic applications; Therapeutic targets; Wound healing; skin cells; dermatology; non‐neuronal cholinergic systems; inflammation

The pivotal roles of acetylcholine (ACh) in physiological processes encompass both the nervous and non‐neuronal cholinergic systems (NNCS). This review delineates the synthesis, release, receptor interactions, and degradation of ACh within the nervous system, and explores the NNCS in depth within sk...