Safety and efficacy of teplizumab in the treatment of type 1 diabetes mellitus: An updated systematic review and meta‐analysis of randomized controlled trials

• Published in: Diabetes, obesity & metabolism Vol. 26; no. 7; pp. 2652 - 2661
• Main Authors: Grando Alves, Gabriel, Cunha, Luisa, Henkes Machado, Rafael, Lins de Menezes, Vanessa
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2024; Wiley Subscription Services, Inc
• Subjects: Adverse events; anti‐CD3 monoclonal antibody; Clinical trials; C‐peptide; Diabetes; Diabetes mellitus (insulin dependent); Hemoglobin; Insulin; Meta-analysis; Monoclonal antibodies; Peptides; Statistical analysis; Statistics; systematic review; T1DM; teplizumab; type 1 diabetes mellitus; T1DM; teplizumab; type 1 diabetes mellitus; meta‐analysis; systematic review; C‐peptide; anti‐CD3 monoclonal antibody

Aim To provide updated efficacy and safety information for teplizumab in the treatment of Stage 3 type 1 diabetes mellitus (T1DM). Materials and Methods The PubMed, Embase and Cochrane databases were searched for randomized controlled trials (RCTs) comparing teplizumab to placebo for T1DM that repor...