CBL/Cbl‐b mediates Fas degradation to reduce neuronal damage in experimental autoimmune encephalomyelitis

• Published in: Scandinavian journal of immunology Vol. 101; no. 1; pp. e13430 - n/a
• Main Authors: Guan, Dongsheng, Li, Yingxia, Chen, Binyan, Wang, Kun, Guo, Yanke, Dong, Ning, Cui, Yinglin, Gao, Yinghe, Wang, Mengmeng, Wang, Jing, Ren, Yihan, Shang, Penghui, Liu, Yuxuan
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2025
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animal models; Animals; CBL; Cbl protein; Cbl‐b; Cell culture; Cell Differentiation; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - metabolism; Experimental allergic encephalomyelitis; experimental autoimmune encephalomyelitis; fas Receptor - genetics; fas Receptor - metabolism; Female; Flow cytometry; Helper cells; Humans; Immunofluorescence; Leupeptins - pharmacology; Lymphocytes T; Mice; Mice, Inbred C57BL; mRNA; Neurons - metabolism; Neurons - pathology; Proteasome inhibitors; Proteasomes; Proteins; Proteolysis; Proto-Oncogene Proteins c-cbl - genetics; Proto-Oncogene Proteins c-cbl - metabolism; Spinal cord; Spinal Cord - metabolism; Spinal Cord - pathology; Spinal cord injuries; Th17 Cells - immunology; Th17 Cells - metabolism; Therapeutic targets; T‐helper 17 cells; Ubiquitin-protein ligase; Ubiquitination; ubiquitination modification; T‐helper 17 cells; ubiquitination modification; experimental autoimmune encephalomyelitis; CBL; Cbl‐b

Fas has been shown to positively regulate the differentiation of T helper 17 (Th17) cells in mouse models of experimental autoimmune encephalomyelitis (EAE). Fas protein expression is regulated by ubiquitination but has not been further studied. In this study, we investigated the role of the Fas ubi...