Structure‐based design, synthesis, and biological characterization of indolylarylsulfone derivatives as novel human immunodeficiency virus type 1 inhibitors with potent antiviral activities and favorable drug‐like profiles

• Published in: Journal of medical virology Vol. 96; no. 8; pp. e29830 - n/a
• Main Authors: Wang, Zhao, Wang, Wenbo, Gao, Zhen, Gao, Huizhan, Clercq, Erik De, Pannecouque, Christophe, Chen, Chin‐Ho, Kang, Dongwei, Zhan, Peng, Liu, Xinyong
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2024
• Subjects: Anti-HIV Agents - chemical synthesis; Anti-HIV Agents - chemistry; Anti-HIV Agents - pharmacology; Antiretroviral agents; Antiretroviral drugs; Antiviral drugs; Biological activity; Biological effects; biological evaluation; Biological properties; Blood plasma; Chemical synthesis; Crystallography; Cytochrome P450; Cytochromes P450; Cytotoxicity; Disease resistance; Drug Design; Drug development; Drug resistance; Effectiveness; HIV; HIV Reverse Transcriptase - antagonists & inhibitors; HIV Reverse Transcriptase - metabolism; HIV-1 - drug effects; HIV‐1; Human immunodeficiency virus; Humans; Immune system; indolylarylsulfone derivatives; Inhibitors; Lead compounds; Microsomes; Molecular docking; Molecular Docking Simulation; molecular dynamics simulation; Molecular structure; Nucleoside reverse transcriptase inhibitors; Physicochemical properties; Reverse Transcriptase Inhibitors - chemical synthesis; Reverse Transcriptase Inhibitors - chemistry; Reverse Transcriptase Inhibitors - pharmacology; RNA-directed DNA polymerase; Structure-Activity Relationship; structure‐based design; Sulfones - chemical synthesis; Sulfones - chemistry; Sulfones - pharmacology; Toxicity testing; HIV‐1; structure‐based design; biological evaluation; molecular dynamics simulation; indolylarylsulfone derivatives

In the current antiretroviral landscape, continuous efforts are still needed to search for novel chemotypes of human immunodeficiency virus type 1 (HIV‐1) inhibitors with improved drug resistance profiles and favorable drug‐like properties. Herein, we report the design, synthesis, biological charact...