Structure‐based design, synthesis, and biological characterization of indolylarylsulfone derivatives as novel human immunodeficiency virus type 1 inhibitors with potent antiviral activities and favorable drug‐like profiles - Wang, Zhao; Wang, Wenbo; Gao, Zhen; Gao, Huizhan; Clercq, Erik De; Pannecouque, Christophe; Chen, Chin‐Ho; Kang, Dongwei; Zhan, Peng; Liu, Xinyong (Journal of medical virology, 2024)
Keywords: Anti-HIV Agents - chemical synthesis; Anti-HIV Agents - chemistry; Anti-HIV Agents - pharmacology; Antiretroviral agents; Antiretroviral drugs; Antiviral drugs; Biological activity; Biological effects; biological evaluation; Biological properties; Blood plasma; Chemical synthesis; Crystallography; Cytochrome P450; Cytochromes P450; Cytotoxicity; Disease resistance; Drug Design; Drug development; Drug resistance; Effectiveness; HIV; HIV Reverse Transcriptase - antagonists & inhibitors; HIV Reverse Transcriptase - metabolism; HIV-1 - drug effects; HIV‐1; Human immunodeficiency virus; Humans; Immune system; indolylarylsulfone derivatives; Inhibitors; Lead compounds; Microsomes; Molecular docking; Molecular Docking Simulation; molecular dynamics simulation; Molecular structure; Nucleoside reverse transcriptase inhibitors; Physicochemical properties; Reverse Transcriptase Inhibitors - chemical synthesis; Reverse Transcriptase Inhibitors - chemistry; Reverse Transcriptase Inhibitors - pharmacology; RNA-directed DNA polymerase; Structure-Activity Relationship; structure‐based design; Sulfones - chemical synthesis; Sulfones - chemistry; Sulfones - pharmacology; Toxicity testing; HIV‐1; structure‐based design; biological evaluation; molecular dynamics simulation; indolylarylsulfone derivatives