Irinotecan and chronomodulated infusion of 5-fluorouracil and folinic acid in the treatment of patients with advanced colorectal carcinoma a Phase I study

• Published in: Cancer Vol. 91; no. 4; pp. 712 - 720
• Main Authors: GARUFI, Carlo, DOGLIOTTI, Luigi, D'ATTINO, Rita M, TAMPELLINI, Marco, ASCHELTER, Anna M, PUGLIESE, Patrizia, PERRONE, Maria, NISTICO, Cecilia, COMIS, Silvia, TERZOLI, Edmondo
• Format: Journal Article
• Language: English
• Published: New York, NY Wiley-Liss 15.02.2001
• Subjects: Adult; Aged; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Camptothecin - administration & dosage; Camptothecin - analogs & derivatives; Chemotherapy; Chronotherapy; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - pathology; Female; Fluorouracil - administration & dosage; Humans; Leucovorin - administration & dosage; Male; Medical sciences; Middle Aged; Neoplasm Metastasis; Pharmacology. Drug treatments; Quality of Life; Antineoplastic agent; Rectal disease; Carcinoma; Intravenous administration; Calcium folinate; Biological rhythm; Isomerases; Chronobiology; Intestinal disease; Advanced stage; Colon; Fluorouracil; Human; Drug combination; Enzyme; Maximal dose; Fluoropyrimidine derivatives; DNA topoisomerase; Enzyme inhibitor; Malignant tumor; Biological activity; Quality of life; Colonic disease; Irinotecan; Chemotherapy; Treatment; Rectum; Phase I trial; Digestive diseases; Pyrimidine derivatives; Fluorine Organic compounds

Irinotecan (CPT-11) is an active drug in the treatment of patients with advanced colorectal carcinoma. The infusion of 5-fluorouracil (5-FU) according to circadian rhythms was used previously to decrease toxicity and to increase its therapeutic efficacy. The objective of this study was to establish...