The chemical transformation of β-bromodifluoromethyl β-enaminoketones: Synthesis of difluoromethylene thioether compounds
A series of 2-bromodifluoromethylquinoline derivatives were synthesized by cyclization of β-bromodifluoromethyl β-enaminoketones catalyzed by polyphosphoric acid. Difluoromethylene thioether or ether derivatives of quinoline and but-2-en-1-one were obtained by the subustitute reaction of CF 2Br with...
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Published in | Journal of fluorine chemistry Vol. 127; no. 2; pp. 223 - 228 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
LAUSANNE
Elsevier B.V
01.02.2006
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | A series of 2-bromodifluoromethylquinoline derivatives were synthesized by cyclization of β-bromodifluoromethyl β-enaminoketones catalyzed by polyphosphoric acid. Difluoromethylene thioether or ether derivatives of quinoline and but-2-en-1-one were obtained by the subustitute reaction of CF
2Br with thio- and oxygen nucleophiles. |
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ISSN: | 0022-1139 1873-3328 |
DOI: | 10.1016/j.jfluchem.2005.10.015 |