Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 70; no. 4; pp. 373 - 376
• Main Author: Leslie, Christina C
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier 01.04.2004
• Subjects: Animals; Arachidonic Acid - secretion; Biological and medical sciences; Cell Membrane - enzymology; Cell Membrane - metabolism; Cytosol - enzymology; Fundamental and applied biological sciences. Psychology; Humans; Phospholipases A - metabolism; Phospholipases A2; Vertebrates: endocrinology; n-6 fatty acid; Enzyme; Polyunsaturated fatty acid; Unsaturated fatty acid; Hydrolases; Lipids; Esterases; Arachidonic acid; Phospholipase A; Release; Carboxylic ester hydrolases

Cytosolic phospholipase A(2) alpha (cPLA(2)alpha) is the only PLA(2) that exhibits specificity for sn-2 arachidonic acid consistent with its primary role in mediating the agonist-induced release of arachidonic acid for eicosanoid production. It is subject to complex mechanisms of regulation that ens...