Syndecans in hematopoietic cells and their niches

• Published in: American Journal of Physiology: Cell Physiology Vol. 327; no. 2; pp. C372 - C378
• Main Authors: Hagen, Matthew W, Setiawan, Nicollette J, Woodruff, Kelsey A, Termini, Christina M
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2024
• Subjects: Bioavailability; Cell adhesion; Cell migration; Cell signaling; Glycoproteins; Growth factors; Hematopoietic stem cells; Heparan sulfate; Heparan sulfate proteoglycans; Lymphoma; Malignancy; Microenvironments; Mini-Review; Syndecan; Proteoglycan; Bone marrow niche; Hematopoiesis; Leukemia; Syndecan

Heparan sulfate proteoglycans are a family of glycoproteins that modulate cell signaling by binding growth factors and changing their bioavailability. Syndecans are a specific family of transmembrane heparan sulfate proteoglycans that regulate cell adhesion, migration, and signaling. In this review,...