Ion transport and enteric nervous system (ENS) in rat rectal colon: mechanical stretch causes electrogenic Cl-secretion via plexus Meissner and amiloride-sensitive electrogenic Na-absorption is not affected by intramural neurons

• Published in: Pflügers Archiv Vol. 414; no. 2; p. 216
• Main Authors: Schulzke, J D, Fromm, M, Hegel, U, Riecken, E O
• Format: Journal Article
• Language: English
• Published: Germany 01.06.1989
• Subjects: Absorption; Amiloride - pharmacology; Animals; Biological Transport; Chlorides - metabolism; Colon - innervation; Colon - metabolism; Electric Stimulation; Electrophysiology; Ions; Male; Nervous System - cytology; Nervous System Physiological Phenomena; Neurons - physiology; Physical Stimulation; Rats; Rats, Inbred Strains; Rectum; Sodium - pharmacokinetics; Submucous Plexus - metabolism; Tetrodotoxin - pharmacology

The initial phase of in vitro experiments in Ussing-type chambers on large intestine is characterized by short-circuit currents (ISC) declining from high starting values to a lower plateau within 0.5 h. The origin of this "initial ISC-transient" was investigated by ISC measurements on part...