Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis

Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associ...

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Published inNature (London) Vol. 634; no. 8033; pp. 457 - 465
Main Authors Takaoka, Minoru, Zhao, Xiaohui, Lim, Hwee Ying, Magnussen, Costan G., Ang, Owen, Suffee, Nadine, Schrank, Patricia R., Ong, Wei Siong, Tsiantoulas, Dimitrios, Sommer, Felix, Mohanta, Sarajo K., Harrison, James, Meng, Yaxing, Laurans, Ludivine, Wu, Feitong, Lu, Yuning, Masters, Leanne, Newland, Stephen A., Denti, Laura, Hong, Mingyang, Chajadine, Mouna, Juonala, Markus, Koskinen, Juhani S., Kähönen, Mika, Pahkala, Katja, Rovio, Suvi P., Mykkänen, Juha, Thomson, Russell, Kaisho, Tsuneyasu, Habenicht, Andreas J. R., Clement, Marc, Tedgui, Alain, Ait-Oufella, Hafid, Zhao, Tian X., Nus, Meritxell, Ruhrberg, Christiana, Taleb, Soraya, Williams, Jesse W., Raitakari, Olli T., Angeli, Véronique, Mallat, Ziad
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 10.10.2024
Nature Publishing Group
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13
13/1
13/51
14/19
631/443
631/443/592
64
Actin
Antibiotics
Arteriosclerosis
Atherosclerosis
Autophagy
Biological effects
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Experiments
Exposure
Genes
Genome-wide association studies
Health risks
High cholesterol diet
Humanities and Social Sciences
Hyperlipidemia
Low density lipoprotein
Macrophages
Microbiota
multidisciplinary
Optimal control
Phenotypes
Plasma
Risk factors
Science
Science (multidisciplinary)
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Abstract Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk 1 . Furthermore, LDL-C fluctuations are associated with ASCVD outcomes 2 – 4 . However, the precise mechanisms behind this increased ASCVD risk are not understood. Here we find that early intermittent feeding of mice on a high-cholesterol Western-type diet (WD) accelerates atherosclerosis compared with late continuous exposure to the WD, despite similar cumulative circulating LDL-C levels. We find that early intermittent hyperlipidaemia alters the number and homeostatic phenotype of resident-like arterial macrophages. Macrophage genes with altered expression are enriched for genes linked to human ASCVD in genome-wide association studies. We show that LYVE1 + resident macrophages are atheroprotective, and identify biological pathways related to actin filament organization, of which alteration accelerates atherosclerosis. Using the Young Finns Study, we show that exposure to cholesterol early in life is significantly associated with the incidence and size of carotid atherosclerotic plaques in mid-adulthood. In summary, our results identify early intermittent exposure to cholesterol as a strong determinant of accelerated atherosclerosis, highlighting the importance of optimal control of hyperlipidaemia early in life, and providing insights into the underlying biological mechanisms. This knowledge will be essential to designing effective therapeutic strategies to combat ASCVD. Early intermittent feeding of mice with a high-cholesterol Western-type diet accelerates atherosclerosis compared with late continuous exposure to the Western-type diet, despite similar cumulative circulating LDL-C levels.
AbstractList Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk . Furthermore, LDL-C fluctuations are associated with ASCVD outcomes . However, the precise mechanisms behind this increased ASCVD risk are not understood. Here we find that early intermittent feeding of mice on a high-cholesterol Western-type diet (WD) accelerates atherosclerosis compared with late continuous exposure to the WD, despite similar cumulative circulating LDL-C levels. We find that early intermittent hyperlipidaemia alters the number and homeostatic phenotype of resident-like arterial macrophages. Macrophage genes with altered expression are enriched for genes linked to human ASCVD in genome-wide association studies. We show that LYVE1 resident macrophages are atheroprotective, and identify biological pathways related to actin filament organization, of which alteration accelerates atherosclerosis. Using the Young Finns Study, we show that exposure to cholesterol early in life is significantly associated with the incidence and size of carotid atherosclerotic plaques in mid-adulthood. In summary, our results identify early intermittent exposure to cholesterol as a strong determinant of accelerated atherosclerosis, highlighting the importance of optimal control of hyperlipidaemia early in life, and providing insights into the underlying biological mechanisms. This knowledge will be essential to designing effective therapeutic strategies to combat ASCVD.
Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk 1 . Furthermore, LDL-C fluctuations are associated with ASCVD outcomes 2 – 4 . However, the precise mechanisms behind this increased ASCVD risk are not understood. Here we find that early intermittent feeding of mice on a high-cholesterol Western-type diet (WD) accelerates atherosclerosis compared with late continuous exposure to the WD, despite similar cumulative circulating LDL-C levels. We find that early intermittent hyperlipidaemia alters the number and homeostatic phenotype of resident-like arterial macrophages. Macrophage genes with altered expression are enriched for genes linked to human ASCVD in genome-wide association studies. We show that LYVE1 + resident macrophages are atheroprotective, and identify biological pathways related to actin filament organization, of which alteration accelerates atherosclerosis. Using the Young Finns Study, we show that exposure to cholesterol early in life is significantly associated with the incidence and size of carotid atherosclerotic plaques in mid-adulthood. In summary, our results identify early intermittent exposure to cholesterol as a strong determinant of accelerated atherosclerosis, highlighting the importance of optimal control of hyperlipidaemia early in life, and providing insights into the underlying biological mechanisms. This knowledge will be essential to designing effective therapeutic strategies to combat ASCVD. Early intermittent feeding of mice with a high-cholesterol Western-type diet accelerates atherosclerosis compared with late continuous exposure to the Western-type diet, despite similar cumulative circulating LDL-C levels.
Abstract Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk 1 . Furthermore, LDL-C fluctuations are associated with ASCVD outcomes 2–4 . However, the precise mechanisms behind this increased ASCVD risk are not understood. Here we find that early intermittent feeding of mice on a high-cholesterol Western-type diet (WD) accelerates atherosclerosis compared with late continuous exposure to the WD, despite similar cumulative circulating LDL-C levels. We find that early intermittent hyperlipidaemia alters the number and homeostatic phenotype of resident-like arterial macrophages. Macrophage genes with altered expression are enriched for genes linked to human ASCVD in genome-wide association studies. We show that LYVE1 + resident macrophages are atheroprotective, and identify biological pathways related to actin filament organization, of which alteration accelerates atherosclerosis. Using the Young Finns Study, we show that exposure to cholesterol early in life is significantly associated with the incidence and size of carotid atherosclerotic plaques in mid-adulthood. In summary, our results identify early intermittent exposure to cholesterol as a strong determinant of accelerated atherosclerosis, highlighting the importance of optimal control of hyperlipidaemia early in life, and providing insights into the underlying biological mechanisms. This knowledge will be essential to designing effective therapeutic strategies to combat ASCVD.
Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk1. Furthermore, LDL-C fluctuations are associated with ASCVD outcomes2-4. However, the precise mechanisms behind this increased ASCVD risk are not understood. Here we find that early intermittent feeding of mice on a high-cholesterol Western-type diet (WD) accelerates atherosclerosis compared with late continuous exposure to the WD, despite similar cumulative circulating LDL-C levels. We find that early intermittent hyperlipidaemia alters the number and homeostatic phenotype of resident-like arterial macrophages. Macrophage genes with altered expression are enriched for genes linked to human ASCVD in genome-wide association studies. We show that LYVE1+ resident macrophages are atheroprotective, and identify biological pathways related to actin filament organization, of which alteration accelerates atherosclerosis. Using the Young Finns Study, we show that exposure to cholesterol early in life is significantly associated with the incidence and size of carotid atherosclerotic plaques in mid-adulthood. In summary, our results identify early intermittent exposure to cholesterol as a strong determinant of accelerated atherosclerosis, highlighting the importance of optimal control of hyperlipidaemia early in life, and providing insights into the underlying biological mechanisms. This knowledge will be essential to designing effective therapeutic strategies to combat ASCVD.Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk1. Furthermore, LDL-C fluctuations are associated with ASCVD outcomes2-4. However, the precise mechanisms behind this increased ASCVD risk are not understood. Here we find that early intermittent feeding of mice on a high-cholesterol Western-type diet (WD) accelerates atherosclerosis compared with late continuous exposure to the WD, despite similar cumulative circulating LDL-C levels. We find that early intermittent hyperlipidaemia alters the number and homeostatic phenotype of resident-like arterial macrophages. Macrophage genes with altered expression are enriched for genes linked to human ASCVD in genome-wide association studies. We show that LYVE1+ resident macrophages are atheroprotective, and identify biological pathways related to actin filament organization, of which alteration accelerates atherosclerosis. Using the Young Finns Study, we show that exposure to cholesterol early in life is significantly associated with the incidence and size of carotid atherosclerotic plaques in mid-adulthood. In summary, our results identify early intermittent exposure to cholesterol as a strong determinant of accelerated atherosclerosis, highlighting the importance of optimal control of hyperlipidaemia early in life, and providing insights into the underlying biological mechanisms. This knowledge will be essential to designing effective therapeutic strategies to combat ASCVD.
Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk1. Furthermore, LDL-C fluctuations are associated with ASCVD outcomes2 4. However, the precise mechanisms behind this increased ASCVD risk are not understood. Here we find that early intermittent feeding of mice on a high-cholesterol Western-type diet (WD) accelerates atherosclerosis compared with late continuous exposure to the WD, despite similar cumulative circulating LDL-C levels. We find that early intermittent hyperlipidaemia alters the number and homeostatic phenotype of resident-like arterial macrophages. Macrophage genes with altered expression are enriched for genes linked to human ASCVD in genome-wide association studies. We show that LYVE1+ resident macrophages are atheroprotective, and identify biological pathways related to actin filament organization, of which alteration accelerates atherosclerosis. Using the Young Finns Study, we show that exposure to cholesterol early in life is significantly associated with the incidence and size of carotid atherosclerotic plaques in mid-adulthood. In summary, our results identify early intermittent exposure to cholesterol as a strong determinant of accelerated atherosclerosis, highlighting the importance of optimal control of hyperlipidaemia early in life, and providing insights into the underlying biological mechanisms. This knowledge will be essential to designing effective therapeutic strategies to combat ASCVD.
Author Koskinen, Juhani S.
Williams, Jesse W.
Ong, Wei Siong
Kähönen, Mika
Pahkala, Katja
Magnussen, Costan G.
Lim, Hwee Ying
Nus, Meritxell
Wu, Feitong
Harrison, James
Raitakari, Olli T.
Mallat, Ziad
Newland, Stephen A.
Laurans, Ludivine
Masters, Leanne
Sommer, Felix
Meng, Yaxing
Ang, Owen
Lu, Yuning
Chajadine, Mouna
Suffee, Nadine
Zhao, Tian X.
Kaisho, Tsuneyasu
Habenicht, Andreas J. R.
Schrank, Patricia R.
Juonala, Markus
Taleb, Soraya
Ruhrberg, Christiana
Angeli, Véronique
Zhao, Xiaohui
Ait-Oufella, Hafid
Mohanta, Sarajo K.
Hong, Mingyang
Rovio, Suvi P.
Tedgui, Alain
Tsiantoulas, Dimitrios
Takaoka, Minoru
Denti, Laura
Thomson, Russell
Mykkänen, Juha
Clement, Marc
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Cites_doi 10.1126/sciimmunol.aan4626
10.1038/ng.327
10.3389/fonc.2018.00515
10.1093/eurheartj/ehz458
10.1038/ng.2480
10.1038/s41587-020-0439-x
10.5281/zenodo.13137366
10.1038/ni.3343
10.1038/s41587-021-01206-w
10.1001/jamacardio.2020.7238
10.1016/j.jacc.2020.07.059
10.1161/ATVBAHA.118.311233
10.1038/s41590-020-0768-4
10.1093/nar/gkz369
10.1038/s41586-022-04673-6
10.1093/ije/dyy107
10.1093/eurheartj/ehx585
10.1186/s13059-014-0550-8
10.1016/j.celrep.2016.01.026
10.1016/j.jcmgh.2020.03.008
10.1038/s41591-022-01891-3
10.1161/01.ATV.0000090126.34881.B1
10.1073/pnas.92.18.8264
10.1016/j.celrep.2015.05.018
10.1038/ismej.2012.8
10.1038/s41588-022-01233-6
10.1038/s41591-018-0336-8
10.1172/JCI117179
10.1016/j.cellsig.2011.09.003
10.1038/nbt.3820
10.1002/cpz1.90
10.1038/nature00804
10.1016/j.cmet.2012.01.022
10.18637/jss.v076.i01
10.1371/journal.pone.0146081
10.1161/ATVBAHA.115.305534
10.1371/journal.pone.0085254
10.1161/01.CIR.0000057548.68243.42
10.1161/ATVBAHA.111.237693
10.1093/cvr/cvac161
10.1056/NEJMoa1912387
10.1001/jama.290.17.2277
10.1016/j.jacc.2015.02.017
10.1161/ATVBAHA.123.320065
10.1016/j.atherosclerosis.2019.11.029
10.1161/CIRCULATIONAHA.118.034978
10.1172/JCI145275
10.1038/s41591-019-0590-4
10.1084/jem.20132330
10.1038/s41586-021-03534-y
10.1056/NEJMoa1816454
10.1161/ATVBAHA.112.300112
10.1038/nature08938
10.1161/CIRCRESAHA.117.312509
10.1186/1471-2105-14-128
10.3389/fcvm.2017.00086
10.1002/hep.1840080245
10.1056/NEJMoa1707914
10.1161/CIRCRESAHA.118.312804
10.1016/j.cell.2022.10.007
10.1089/omi.2011.0118
10.1016/j.cell.2019.05.031
10.1016/j.immuni.2018.06.008
10.1093/nar/gkw377
10.1038/s41467-022-35604-8
10.1126/science.abj5117
10.1161/CIRCRESAHA.120.317200
10.1073/pnas.1808426115
10.1161/ATV.0000000000000062
ContentType Journal Article
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References Yin (CR63) 2019; 25
Tcheandjieu (CR28) 2022; 28
Getz, Reardon (CR8) 2012; 32
Di Tommaso (CR51) 2017; 35
Huan (CR19) 2013; 33
Daugherty (CR46) 2017; 37
Duewell (CR5) 2010; 464
Chen (CR58) 2013; 14
Bangalore (CR4) 2015; 65
Sommer (CR47) 2014; 9
Madathil, Joseph, Hardy, Rousseau, Nicolau (CR65) 2018; 47
CR70
Caporaso (CR49) 2012; 6
Kim (CR2) 2017; 38
Smith (CR12) 1995; 92
Williams (CR16) 2020; 21
Aragam (CR33) 2022; 54
Abell (CR18) 2022; 375
Park, Silvin, Ginhoux, Merad (CR38) 2022; 185
Teupser, Persky, Breslow (CR10) 2003; 23
Kuleshov (CR59) 2016; 44
Liao (CR13) 2012; 15
Cochain (CR22) 2018; 122
Gayoso (CR57) 2022; 40
Domanski (CR1) 2020; 76
Luirink (CR41) 2019; 381
Raitakari (CR35) 2003; 290
Carpenter (CR69) 2017; 76
Ensan (CR40) 2016; 17
Love, Huber, Anders (CR53) 2014; 15
Combadiere (CR39) 2003; 107
Raudvere (CR61) 2019; 47
Kim (CR23) 2018; 123
Buscot (CR67) 2016; 11
Ishibashi, Goldstein, Brown, Herz, Burns (CR7) 1994; 93
Sommer (CR48) 2016; 14
Wilson (CR34) 2018; 3
Vafadarnejad (CR24) 2020; 127
Wu (CR55) 2021; 2
Xie (CR60) 2021; 1
Stuart (CR56) 2019; 177
Ridker (CR6) 2017; 377
Beaudoin (CR27) 2015; 35
Musunuru (CR44) 2021; 593
Allain (CR32) 2012; 24
Jeejeebhoy (CR64) 1988; 8
Madathil, Blaser, Nicolau, Richard, Parent (CR66) 2018; 8
Mohanta (CR62) 2022; 605
Kim (CR3) 2018; 138
Armstrong (CR68) 2021; 6
Fantin (CR31) 2015; 11
Ewels (CR52) 2020; 38
Kasikara (CR17) 2021; 131
Koskinen (CR36) 2020; 293
Shi (CR14) 2022; 13
Raimondi (CR30) 2014; 211
CR25
Lim (CR21) 2018; 49
Yu, Wang, Han, He (CR54) 2012; 16
Kayama (CR45) 2018; 115
CR20
Fernandez (CR29) 2019; 25
Giral, Neumann, Weill, Coste (CR37) 2019; 40
Consortium (CR26) 2013; 45
Williams (CR42) 2024; 44
Skalen (CR9) 2002; 417
Yurdagul, Doran, Cai, Fredman, Tabas (CR15) 2017; 4
Ray (CR43) 2020; 382
Lindskog Jonsson (CR11) 2018; 38
Moltzau Anderson (CR50) 2020; 10
AM Wilson (7993_CR34) 2018; 3
PA Ewels (7993_CR52) 2020; 38
MK Kim (7993_CR3) 2018; 138
G Yu (7993_CR54) 2012; 16
MV Kuleshov (7993_CR59) 2016; 44
U Raudvere (7993_CR61) 2019; 47
C Combadiere (7993_CR39) 2003; 107
J Moltzau Anderson (7993_CR50) 2020; 10
KK Ray (7993_CR43) 2020; 382
MI Love (7993_CR53) 2014; 15
T Stuart (7993_CR56) 2019; 177
B Allain (7993_CR32) 2012; 24
7993_CR70
C Kasikara (7993_CR17) 2021; 131
Z Xie (7993_CR60) 2021; 1
A Gayoso (7993_CR57) 2022; 40
K Musunuru (7993_CR44) 2021; 593
JS Koskinen (7993_CR36) 2020; 293
JW Williams (7993_CR16) 2020; 21
PM Ridker (7993_CR6) 2017; 377
F Sommer (7993_CR47) 2014; 9
S Ensan (7993_CR40) 2016; 17
MJ Buscot (7993_CR67) 2016; 11
GS Getz (7993_CR8) 2012; 32
B Carpenter (7993_CR69) 2017; 76
MJ Domanski (7993_CR1) 2020; 76
7993_CR20
JD Smith (7993_CR12) 1995; 92
P Di Tommaso (7993_CR51) 2017; 35
7993_CR25
JG Caporaso (7993_CR49) 2012; 6
MK Kim (7993_CR2) 2017; 38
NS Abell (7993_CR18) 2022; 375
IK Luirink (7993_CR41) 2019; 381
S Madathil (7993_CR66) 2018; 8
M Beaudoin (7993_CR27) 2015; 35
MK Armstrong (7993_CR68) 2021; 6
S Ishibashi (7993_CR7) 1994; 93
D Teupser (7993_CR10) 2003; 23
H Kayama (7993_CR45) 2018; 115
A Lindskog Jonsson (7993_CR11) 2018; 38
X Liao (7993_CR13) 2012; 15
KJ Williams (7993_CR42) 2024; 44
S Madathil (7993_CR65) 2018; 47
CAD Consortium (7993_CR26) 2013; 45
F Sommer (7993_CR48) 2016; 14
P Duewell (7993_CR5) 2010; 464
C Tcheandjieu (7993_CR28) 2022; 28
DM Fernandez (7993_CR29) 2019; 25
KN Jeejeebhoy (7993_CR64) 1988; 8
C Cochain (7993_CR22) 2018; 122
KG Aragam (7993_CR33) 2022; 54
A Yurdagul Jr (7993_CR15) 2017; 4
OT Raitakari (7993_CR35) 2003; 290
S Bangalore (7993_CR4) 2015; 65
P Giral (7993_CR37) 2019; 40
E Vafadarnejad (7993_CR24) 2020; 127
K Kim (7993_CR23) 2018; 123
T Huan (7993_CR19) 2013; 33
C Raimondi (7993_CR30) 2014; 211
C Yin (7993_CR63) 2019; 25
A Fantin (7993_CR31) 2015; 11
EY Chen (7993_CR58) 2013; 14
J Shi (7993_CR14) 2022; 13
A Daugherty (7993_CR46) 2017; 37
T Wu (7993_CR55) 2021; 2
SK Mohanta (7993_CR62) 2022; 605
K Skalen (7993_CR9) 2002; 417
MD Park (7993_CR38) 2022; 185
HY Lim (7993_CR21) 2018; 49
References_xml – volume: 38
  start-page: 276
  year: 2020
  end-page: 278
  ident: CR52
  article-title: The nf-core framework for community-curated bioinformatics pipelines
  publication-title: Nat. Biotechnol.
  contributor:
    fullname: Ewels
– ident: CR70
– volume: 211
  start-page: 1167
  year: 2014
  end-page: 1183
  ident: CR30
  article-title: Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells
  publication-title: J. Exp. Med.
  contributor:
    fullname: Raimondi
– volume: 65
  start-page: 1539
  year: 2015
  end-page: 1548
  ident: CR4
  article-title: Visit-to-visit low-density lipoprotein cholesterol variability and risk of cardiovascular outcomes: insights from the TNT trial
  publication-title: J. Am. Coll. Cardiol.
  contributor:
    fullname: Bangalore
– volume: 382
  start-page: 1507
  year: 2020
  end-page: 1519
  ident: CR43
  article-title: Two phase 3 trials of inclisiran in patients with elevated LDL cholesterol
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Ray
– volume: 593
  start-page: 429
  year: 2021
  end-page: 434
  ident: CR44
  article-title: In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
  publication-title: Nature
  contributor:
    fullname: Musunuru
– volume: 15
  start-page: 545
  year: 2012
  end-page: 553
  ident: CR13
  article-title: Macrophage autophagy plays a protective role in advanced atherosclerosis
  publication-title: Cell Metab.
  contributor:
    fullname: Liao
– volume: 14
  start-page: 128
  year: 2013
  ident: CR58
  article-title: Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
  publication-title: BMC Bioinform.
  contributor:
    fullname: Chen
– volume: 38
  start-page: 3560
  year: 2017
  end-page: 3566
  ident: CR2
  article-title: Cholesterol variability and the risk of mortality, myocardial infarction, and stroke: a nationwide population-based study
  publication-title: Eur. Heart J.
  contributor:
    fullname: Kim
– volume: 11
  start-page: 1577
  year: 2015
  end-page: 1590
  ident: CR31
  article-title: NRP1 regulates CDC42 activation to promote filopodia formation in endothelial tip cells
  publication-title: Cell Rep.
  contributor:
    fullname: Fantin
– volume: 122
  start-page: 1661
  year: 2018
  end-page: 1674
  ident: CR22
  article-title: Single-cell RNA-seq reveals the transcriptional landscape and heterogeneity of aortic macrophages in murine atherosclerosis
  publication-title: Circ. Res.
  contributor:
    fullname: Cochain
– volume: 28
  start-page: 1679
  year: 2022
  end-page: 1692
  ident: CR28
  article-title: Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
  publication-title: Nat. Med.
  contributor:
    fullname: Tcheandjieu
– ident: CR25
– volume: 44
  start-page: W90
  year: 2016
  end-page: W97
  ident: CR59
  article-title: Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Kuleshov
– volume: 3
  start-page: eaan4626
  year: 2018
  ident: CR34
  article-title: Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome
  publication-title: Sci. Immunol.
  contributor:
    fullname: Wilson
– volume: 40
  start-page: 163
  year: 2022
  end-page: 166
  ident: CR57
  article-title: A Python library for probabilistic analysis of single-cell omics data
  publication-title: Nat. Biotechnol.
  contributor:
    fullname: Gayoso
– volume: 24
  start-page: 214
  year: 2012
  end-page: 223
  ident: CR32
  article-title: Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells
  publication-title: Cell Signal.
  contributor:
    fullname: Allain
– volume: 14
  start-page: 1655
  year: 2016
  end-page: 1661
  ident: CR48
  article-title: The gut microbiota modulates energy metabolism in the hibernating brown bear
  publication-title: Cell Rep.
  contributor:
    fullname: Sommer
– volume: 6
  start-page: 1621
  year: 2012
  end-page: 1624
  ident: CR49
  article-title: Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms
  publication-title: ISME J
  contributor:
    fullname: Caporaso
– volume: 8
  start-page: 515
  year: 2018
  ident: CR66
  article-title: Disadvantageous socioeconomic position at specific life periods may contribute to prostate cancer risk and aggressiveness
  publication-title: Front. Oncol.
  contributor:
    fullname: Parent
– volume: 417
  start-page: 750
  year: 2002
  end-page: 754
  ident: CR9
  article-title: Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
  publication-title: Nature
  contributor:
    fullname: Skalen
– volume: 127
  start-page: e232
  year: 2020
  end-page: e249
  ident: CR24
  article-title: Dynamics of cardiac neutrophil diversity in murine myocardial infarction
  publication-title: Circ. Res.
  contributor:
    fullname: Vafadarnejad
– volume: 32
  start-page: 1104
  year: 2012
  end-page: 1115
  ident: CR8
  article-title: Animal models of atherosclerosis
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  contributor:
    fullname: Reardon
– volume: 17
  start-page: 159
  year: 2016
  end-page: 168
  ident: CR40
  article-title: Self-renewing resident arterial macrophages arise from embryonic CX3CR1 precursors and circulating monocytes immediately after birth
  publication-title: Nat. Immunol.
  contributor:
    fullname: Ensan
– volume: 6
  start-page: 661
  year: 2021
  end-page: 668
  ident: CR68
  article-title: Association of non-high-density lipoprotein cholesterol measured in adolescence, young adulthood, and mid-adulthood with coronary artery calcification measured in mid-adulthood
  publication-title: JAMA Cardiol.
  contributor:
    fullname: Armstrong
– volume: 76
  start-page: 1
  year: 2017
  end-page: 32
  ident: CR69
  article-title: Stan: a probabilistic programming language
  publication-title: J. Stat. Softw.
  contributor:
    fullname: Carpenter
– volume: 23
  start-page: 1907
  year: 2003
  end-page: 1913
  ident: CR10
  article-title: Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6 J and FVB/NJ mice: comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement)
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  contributor:
    fullname: Breslow
– volume: 138
  start-page: 2627
  year: 2018
  end-page: 2637
  ident: CR3
  article-title: Associations of variability in blood pressure, glucose and cholesterol concentrations, and body mass index with mortality and cardiovascular outcomes in the general population
  publication-title: Circulation
  contributor:
    fullname: Kim
– volume: 290
  start-page: 2277
  year: 2003
  end-page: 2283
  ident: CR35
  article-title: Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study
  publication-title: JAMA
  contributor:
    fullname: Raitakari
– volume: 47
  start-page: 1623
  year: 2018
  end-page: 1635
  ident: CR65
  article-title: A Bayesian approach to investigate life course hypotheses involving continuous exposures
  publication-title: Int. J. Epidemiol.
  contributor:
    fullname: Nicolau
– volume: 15
  year: 2014
  ident: CR53
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  contributor:
    fullname: Anders
– volume: 54
  start-page: 1803
  year: 2022
  end-page: 1815
  ident: CR33
  article-title: Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
  publication-title: Nat. Genet.
  contributor:
    fullname: Aragam
– volume: 25
  start-page: 1576
  year: 2019
  end-page: 1588
  ident: CR29
  article-title: Single-cell immune landscape of human atherosclerotic plaques
  publication-title: Nat. Med.
  contributor:
    fullname: Fernandez
– volume: 11
  start-page: e0146081
  year: 2016
  ident: CR67
  article-title: The combined effect of common genetic risk variants on circulating lipoproteins is evident in childhood: a longitudinal analysis of the Cardiovascular Risk in Young Finns Study
  publication-title: PLoS ONE
  contributor:
    fullname: Buscot
– volume: 37
  start-page: e131
  year: 2017
  end-page: e157
  ident: CR46
  article-title: Recommendation on design, execution, and reporting of animal atherosclerosis studies: a scientific statement from the american heart association
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  contributor:
    fullname: Daugherty
– volume: 10
  start-page: 365
  year: 2020
  end-page: 389
  ident: CR50
  article-title: NOD2 influences trajectories of intestinal microbiota recovery after antibiotic perturbation
  publication-title: Cell Mol. Gastroenterol. Hepatol.
  contributor:
    fullname: Moltzau Anderson
– volume: 2
  start-page: 100141
  year: 2021
  ident: CR55
  article-title: clusterProfiler 4.0: a universal enrichment tool for interpreting omics data
  publication-title: Innovation
  contributor:
    fullname: Wu
– volume: 9
  start-page: e85254
  year: 2014
  ident: CR47
  article-title: Altered mucus glycosylation in core 1 -glycan-deficient mice affects microbiota composition and intestinal architecture
  publication-title: PLoS ONE
  contributor:
    fullname: Sommer
– volume: 123
  start-page: 1127
  year: 2018
  end-page: 1142
  ident: CR23
  article-title: Transcriptome analysis reveals nonfoamy rather than foamy plaque macrophages are proinflammatory in atherosclerotic murine models
  publication-title: Circ. Res.
  contributor:
    fullname: Kim
– volume: 375
  start-page: 1247
  year: 2022
  end-page: 1254
  ident: CR18
  article-title: Multiple causal variants underlie genetic associations in humans
  publication-title: Science
  contributor:
    fullname: Abell
– volume: 177
  start-page: 1888
  year: 2019
  end-page: 1902
  ident: CR56
  article-title: Comprehensive Integration of Single-Cell Data
  publication-title: Cell
  contributor:
    fullname: Stuart
– volume: 35
  start-page: 1472
  year: 2015
  end-page: 1479
  ident: CR27
  article-title: Myocardial infarction-associated SNP at 6p24 interferes with MEF2 binding and associates with PHACTR1 expression levels in human coronary arteries
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  contributor:
    fullname: Beaudoin
– volume: 377
  start-page: 1119
  year: 2017
  end-page: 1131
  ident: CR6
  article-title: Antiinflammatory therapy with canakinumab for atherosclerotic disease
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Ridker
– volume: 381
  start-page: 1547
  year: 2019
  end-page: 1556
  ident: CR41
  article-title: 20-year follow-up of statins in children with familial hypercholesterolemia
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Luirink
– volume: 25
  start-page: 496
  year: 2019
  end-page: 506
  ident: CR63
  article-title: ApoE attenuates unresolvable inflammation by complex formation with activated C1q
  publication-title: Nat. Med.
  contributor:
    fullname: Yin
– volume: 131
  start-page: e145275
  year: 2021
  ident: CR17
  article-title: Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Kasikara
– volume: 16
  start-page: 284
  year: 2012
  end-page: 287
  ident: CR54
  article-title: Y. clusterProfiler: an R package for comparing biological themes among gene clusters
  publication-title: OMICS
  contributor:
    fullname: He
– volume: 464
  start-page: 1357
  year: 2010
  end-page: 1361
  ident: CR5
  article-title: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
  publication-title: Nature
  contributor:
    fullname: Duewell
– volume: 47
  start-page: W191
  year: 2019
  end-page: W198
  ident: CR61
  article-title: g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Raudvere
– volume: 21
  start-page: 1194
  year: 2020
  end-page: 1204
  ident: CR16
  article-title: Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression
  publication-title: Nat. Immunol.
  contributor:
    fullname: Williams
– volume: 115
  start-page: 8418
  year: 2018
  end-page: 8423
  ident: CR45
  article-title: Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles
  publication-title: Proc. Natl Acad. Sci. USA
  contributor:
    fullname: Kayama
– volume: 45
  start-page: 25
  year: 2013
  end-page: 33
  ident: CR26
  article-title: Large-scale association analysis identifies new risk loci for coronary artery disease
  publication-title: Nat. Genet.
  contributor:
    fullname: Consortium
– volume: 93
  start-page: 1885
  year: 1994
  end-page: 1893
  ident: CR7
  article-title: Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Burns
– volume: 293
  start-page: 18
  year: 2020
  end-page: 25
  ident: CR36
  article-title: Childhood risk factors and carotid atherosclerotic plaque in adulthood: the Cardiovascular Risk in Young Finns Study
  publication-title: Atherosclerosis
  contributor:
    fullname: Koskinen
– volume: 76
  start-page: 1507
  year: 2020
  end-page: 1516
  ident: CR1
  article-title: Time course of LDL cholesterol exposure and cardiovascular disease event risk
  publication-title: J. Am. Coll. Cardiol.
  contributor:
    fullname: Domanski
– volume: 35
  start-page: 316
  year: 2017
  end-page: 319
  ident: CR51
  article-title: Nextflow enables reproducible computational workflows
  publication-title: Nat. Biotechnol.
  contributor:
    fullname: Di Tommaso
– volume: 38
  start-page: 2318
  year: 2018
  end-page: 2326
  ident: CR11
  article-title: Impact of gut microbiota and diet on the development of atherosclerosis in Mice
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  contributor:
    fullname: Lindskog Jonsson
– volume: 8
  start-page: 428
  year: 1988
  end-page: 429
  ident: CR64
  article-title: Hepatic manifestations of total parenteral nutrition: need for prospective investigation
  publication-title: Hepatology
  contributor:
    fullname: Jeejeebhoy
– volume: 40
  start-page: 3516
  year: 2019
  end-page: 3525
  ident: CR37
  article-title: Cardiovascular effect of discontinuing statins for primary prevention at the age of 75 years: a nationwide population-based cohort study in France
  publication-title: Eur. Heart J.
  contributor:
    fullname: Coste
– volume: 4
  start-page: 86
  year: 2017
  ident: CR15
  article-title: Mechanisms and consequences of defective efferocytosis in atherosclerosis
  publication-title: Front. Cardiovasc. Med.
  contributor:
    fullname: Tabas
– volume: 33
  start-page: 1427
  year: 2013
  end-page: 1434
  ident: CR19
  article-title: A systems biology framework identifies molecular underpinnings of coronary heart disease
  publication-title: Arter. Thromb. Vasc. Biol.
  contributor:
    fullname: Huan
– volume: 107
  start-page: 1009
  year: 2003
  end-page: 1016
  ident: CR39
  article-title: Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice
  publication-title: Circulation
  contributor:
    fullname: Combadiere
– volume: 44
  start-page: 48
  year: 2024
  end-page: 64
  ident: CR42
  article-title: Eradicating atherosclerotic events by targeting early subclinical disease: it is time to retire the therapeutic paradigm of too much, too late
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  contributor:
    fullname: Williams
– volume: 49
  start-page: 326
  year: 2018
  end-page: 341
  ident: CR21
  article-title: Hyaluronan receptor LYVE-1-expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen
  publication-title: Immunity
  contributor:
    fullname: Lim
– volume: 13
  year: 2022
  ident: CR14
  article-title: A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis
  publication-title: Nat. Commun.
  contributor:
    fullname: Shi
– volume: 185
  start-page: 4259
  year: 2022
  end-page: 4279
  ident: CR38
  article-title: Macrophages in health and disease
  publication-title: Cell
  contributor:
    fullname: Merad
– volume: 92
  start-page: 8264
  year: 1995
  end-page: 8268
  ident: CR12
  article-title: Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
  publication-title: Proc. Natl Acad. Sci. USA
  contributor:
    fullname: Smith
– volume: 1
  start-page: e90
  year: 2021
  ident: CR60
  article-title: Gene set knowledge discovery with Enrichr
  publication-title: Curr. Protoc.
  contributor:
    fullname: Xie
– ident: CR20
– volume: 605
  start-page: 152
  year: 2022
  end-page: 159
  ident: CR62
  article-title: Neuroimmune cardiovascular interfaces control atherosclerosis
  publication-title: Nature
  contributor:
    fullname: Mohanta
– volume: 3
  start-page: eaan4626
  year: 2018
  ident: 7993_CR34
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.aan4626
  contributor:
    fullname: AM Wilson
– ident: 7993_CR25
  doi: 10.1038/ng.327
– volume: 8
  start-page: 515
  year: 2018
  ident: 7993_CR66
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2018.00515
  contributor:
    fullname: S Madathil
– volume: 40
  start-page: 3516
  year: 2019
  ident: 7993_CR37
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehz458
  contributor:
    fullname: P Giral
– volume: 45
  start-page: 25
  year: 2013
  ident: 7993_CR26
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2480
  contributor:
    fullname: CAD Consortium
– volume: 38
  start-page: 276
  year: 2020
  ident: 7993_CR52
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0439-x
  contributor:
    fullname: PA Ewels
– ident: 7993_CR70
  doi: 10.5281/zenodo.13137366
– volume: 17
  start-page: 159
  year: 2016
  ident: 7993_CR40
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3343
  contributor:
    fullname: S Ensan
– volume: 40
  start-page: 163
  year: 2022
  ident: 7993_CR57
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-021-01206-w
  contributor:
    fullname: A Gayoso
– volume: 6
  start-page: 661
  year: 2021
  ident: 7993_CR68
  publication-title: JAMA Cardiol.
  doi: 10.1001/jamacardio.2020.7238
  contributor:
    fullname: MK Armstrong
– volume: 76
  start-page: 1507
  year: 2020
  ident: 7993_CR1
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2020.07.059
  contributor:
    fullname: MJ Domanski
– volume: 38
  start-page: 2318
  year: 2018
  ident: 7993_CR11
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.118.311233
  contributor:
    fullname: A Lindskog Jonsson
– volume: 21
  start-page: 1194
  year: 2020
  ident: 7993_CR16
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-020-0768-4
  contributor:
    fullname: JW Williams
– volume: 47
  start-page: W191
  year: 2019
  ident: 7993_CR61
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz369
  contributor:
    fullname: U Raudvere
– volume: 605
  start-page: 152
  year: 2022
  ident: 7993_CR62
  publication-title: Nature
  doi: 10.1038/s41586-022-04673-6
  contributor:
    fullname: SK Mohanta
– volume: 47
  start-page: 1623
  year: 2018
  ident: 7993_CR65
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyy107
  contributor:
    fullname: S Madathil
– volume: 38
  start-page: 3560
  year: 2017
  ident: 7993_CR2
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehx585
  contributor:
    fullname: MK Kim
– volume: 15
  year: 2014
  ident: 7993_CR53
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
  contributor:
    fullname: MI Love
– volume: 14
  start-page: 1655
  year: 2016
  ident: 7993_CR48
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.01.026
  contributor:
    fullname: F Sommer
– volume: 10
  start-page: 365
  year: 2020
  ident: 7993_CR50
  publication-title: Cell Mol. Gastroenterol. Hepatol.
  doi: 10.1016/j.jcmgh.2020.03.008
  contributor:
    fullname: J Moltzau Anderson
– volume: 28
  start-page: 1679
  year: 2022
  ident: 7993_CR28
  publication-title: Nat. Med.
  doi: 10.1038/s41591-022-01891-3
  contributor:
    fullname: C Tcheandjieu
– volume: 23
  start-page: 1907
  year: 2003
  ident: 7993_CR10
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/01.ATV.0000090126.34881.B1
  contributor:
    fullname: D Teupser
– volume: 92
  start-page: 8264
  year: 1995
  ident: 7993_CR12
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.92.18.8264
  contributor:
    fullname: JD Smith
– volume: 11
  start-page: 1577
  year: 2015
  ident: 7993_CR31
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.05.018
  contributor:
    fullname: A Fantin
– volume: 6
  start-page: 1621
  year: 2012
  ident: 7993_CR49
  publication-title: ISME J
  doi: 10.1038/ismej.2012.8
  contributor:
    fullname: JG Caporaso
– volume: 54
  start-page: 1803
  year: 2022
  ident: 7993_CR33
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-022-01233-6
  contributor:
    fullname: KG Aragam
– volume: 25
  start-page: 496
  year: 2019
  ident: 7993_CR63
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0336-8
  contributor:
    fullname: C Yin
– volume: 93
  start-page: 1885
  year: 1994
  ident: 7993_CR7
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI117179
  contributor:
    fullname: S Ishibashi
– volume: 24
  start-page: 214
  year: 2012
  ident: 7993_CR32
  publication-title: Cell Signal.
  doi: 10.1016/j.cellsig.2011.09.003
  contributor:
    fullname: B Allain
– volume: 35
  start-page: 316
  year: 2017
  ident: 7993_CR51
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3820
  contributor:
    fullname: P Di Tommaso
– volume: 1
  start-page: e90
  year: 2021
  ident: 7993_CR60
  publication-title: Curr. Protoc.
  doi: 10.1002/cpz1.90
  contributor:
    fullname: Z Xie
– volume: 417
  start-page: 750
  year: 2002
  ident: 7993_CR9
  publication-title: Nature
  doi: 10.1038/nature00804
  contributor:
    fullname: K Skalen
– volume: 15
  start-page: 545
  year: 2012
  ident: 7993_CR13
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2012.01.022
  contributor:
    fullname: X Liao
– volume: 76
  start-page: 1
  year: 2017
  ident: 7993_CR69
  publication-title: J. Stat. Softw.
  doi: 10.18637/jss.v076.i01
  contributor:
    fullname: B Carpenter
– volume: 11
  start-page: e0146081
  year: 2016
  ident: 7993_CR67
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0146081
  contributor:
    fullname: MJ Buscot
– volume: 35
  start-page: 1472
  year: 2015
  ident: 7993_CR27
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.115.305534
  contributor:
    fullname: M Beaudoin
– volume: 9
  start-page: e85254
  year: 2014
  ident: 7993_CR47
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0085254
  contributor:
    fullname: F Sommer
– volume: 107
  start-page: 1009
  year: 2003
  ident: 7993_CR39
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000057548.68243.42
  contributor:
    fullname: C Combadiere
– volume: 32
  start-page: 1104
  year: 2012
  ident: 7993_CR8
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.111.237693
  contributor:
    fullname: GS Getz
– ident: 7993_CR20
  doi: 10.1093/cvr/cvac161
– volume: 382
  start-page: 1507
  year: 2020
  ident: 7993_CR43
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1912387
  contributor:
    fullname: KK Ray
– volume: 290
  start-page: 2277
  year: 2003
  ident: 7993_CR35
  publication-title: JAMA
  doi: 10.1001/jama.290.17.2277
  contributor:
    fullname: OT Raitakari
– volume: 65
  start-page: 1539
  year: 2015
  ident: 7993_CR4
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2015.02.017
  contributor:
    fullname: S Bangalore
– volume: 44
  start-page: 48
  year: 2024
  ident: 7993_CR42
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.123.320065
  contributor:
    fullname: KJ Williams
– volume: 293
  start-page: 18
  year: 2020
  ident: 7993_CR36
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2019.11.029
  contributor:
    fullname: JS Koskinen
– volume: 2
  start-page: 100141
  year: 2021
  ident: 7993_CR55
  publication-title: Innovation
  contributor:
    fullname: T Wu
– volume: 138
  start-page: 2627
  year: 2018
  ident: 7993_CR3
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.118.034978
  contributor:
    fullname: MK Kim
– volume: 131
  start-page: e145275
  year: 2021
  ident: 7993_CR17
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI145275
  contributor:
    fullname: C Kasikara
– volume: 25
  start-page: 1576
  year: 2019
  ident: 7993_CR29
  publication-title: Nat. Med.
  doi: 10.1038/s41591-019-0590-4
  contributor:
    fullname: DM Fernandez
– volume: 211
  start-page: 1167
  year: 2014
  ident: 7993_CR30
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20132330
  contributor:
    fullname: C Raimondi
– volume: 593
  start-page: 429
  year: 2021
  ident: 7993_CR44
  publication-title: Nature
  doi: 10.1038/s41586-021-03534-y
  contributor:
    fullname: K Musunuru
– volume: 381
  start-page: 1547
  year: 2019
  ident: 7993_CR41
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1816454
  contributor:
    fullname: IK Luirink
– volume: 33
  start-page: 1427
  year: 2013
  ident: 7993_CR19
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.112.300112
  contributor:
    fullname: T Huan
– volume: 464
  start-page: 1357
  year: 2010
  ident: 7993_CR5
  publication-title: Nature
  doi: 10.1038/nature08938
  contributor:
    fullname: P Duewell
– volume: 122
  start-page: 1661
  year: 2018
  ident: 7993_CR22
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.117.312509
  contributor:
    fullname: C Cochain
– volume: 14
  start-page: 128
  year: 2013
  ident: 7993_CR58
  publication-title: BMC Bioinform.
  doi: 10.1186/1471-2105-14-128
  contributor:
    fullname: EY Chen
– volume: 4
  start-page: 86
  year: 2017
  ident: 7993_CR15
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2017.00086
  contributor:
    fullname: A Yurdagul Jr
– volume: 8
  start-page: 428
  year: 1988
  ident: 7993_CR64
  publication-title: Hepatology
  doi: 10.1002/hep.1840080245
  contributor:
    fullname: KN Jeejeebhoy
– volume: 377
  start-page: 1119
  year: 2017
  ident: 7993_CR6
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1707914
  contributor:
    fullname: PM Ridker
– volume: 123
  start-page: 1127
  year: 2018
  ident: 7993_CR23
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.118.312804
  contributor:
    fullname: K Kim
– volume: 185
  start-page: 4259
  year: 2022
  ident: 7993_CR38
  publication-title: Cell
  doi: 10.1016/j.cell.2022.10.007
  contributor:
    fullname: MD Park
– volume: 16
  start-page: 284
  year: 2012
  ident: 7993_CR54
  publication-title: OMICS
  doi: 10.1089/omi.2011.0118
  contributor:
    fullname: G Yu
– volume: 177
  start-page: 1888
  year: 2019
  ident: 7993_CR56
  publication-title: Cell
  doi: 10.1016/j.cell.2019.05.031
  contributor:
    fullname: T Stuart
– volume: 49
  start-page: 326
  year: 2018
  ident: 7993_CR21
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.06.008
  contributor:
    fullname: HY Lim
– volume: 44
  start-page: W90
  year: 2016
  ident: 7993_CR59
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw377
  contributor:
    fullname: MV Kuleshov
– volume: 13
  year: 2022
  ident: 7993_CR14
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-35604-8
  contributor:
    fullname: J Shi
– volume: 375
  start-page: 1247
  year: 2022
  ident: 7993_CR18
  publication-title: Science
  doi: 10.1126/science.abj5117
  contributor:
    fullname: NS Abell
– volume: 127
  start-page: e232
  year: 2020
  ident: 7993_CR24
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.120.317200
  contributor:
    fullname: E Vafadarnejad
– volume: 115
  start-page: 8418
  year: 2018
  ident: 7993_CR45
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1808426115
  contributor:
    fullname: H Kayama
– volume: 37
  start-page: e131
  year: 2017
  ident: 7993_CR46
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATV.0000000000000062
  contributor:
    fullname: A Daugherty
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Snippet Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure...
Abstract Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime...
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SubjectTerms 13
13/1
13/51
14/19
631/443
631/443/592
64
Actin
Antibiotics
Arteriosclerosis
Atherosclerosis
Autophagy
Biological effects
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Experiments
Exposure
Genes
Genome-wide association studies
Health risks
High cholesterol diet
Humanities and Social Sciences
Hyperlipidemia
Low density lipoprotein
Macrophages
Microbiota
multidisciplinary
Optimal control
Phenotypes
Plasma
Risk factors
Science
Science (multidisciplinary)
Title Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis
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https://www.ncbi.nlm.nih.gov/pubmed/39231480
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https://www.proquest.com/docview/3100913410
https://pubmed.ncbi.nlm.nih.gov/PMC11464399
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