Nerve Growth Factor-induced Growth Arrest and Induction of p21 in NIH-3T3 Cells Expressing TrkA

• Published in: The Journal of biological chemistry Vol. 270; no. 52; pp. 30841 - 30844
• Main Author: Decker, Stuart J.
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 29.12.1995

Treatment of NIH-3T3 cells expressing human TrkA with nerve growth factor (NGF) resulted in a rapid cessation of growth. Cells stopped dividing within 24 h of NGF treatment and failed to divide as long as NGF was present, accumulating in the G 1 stage of the cell cycle. NGF caused a prolonged activa...