Kinetics of antisecretory action of a new H2-antagonist, YM-11170, in conscious dogs
The antisecretory property of YM-11170 was compared with that of cimetidine and atropine in the Heidenhain pouch dog. YM-11170 inhibited competitively dimaprit-induced gastric acid secretion in doses of 33 and 100 nmol/kg per h and its antisecretory potency was 148 times more pronounced than that of...
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Published in | European journal of pharmacology Vol. 91; no. 4; p. 371 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
05.08.1983
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Abstract | The antisecretory property of YM-11170 was compared with that of cimetidine and atropine in the Heidenhain pouch dog. YM-11170 inhibited competitively dimaprit-induced gastric acid secretion in doses of 33 and 100 nmol/kg per h and its antisecretory potency was 148 times more pronounced than that of cimetidine. The secretory action of pentagastrin and methacholine was also inhibited by YM-11170 and cimetidine with doses similar to those required for the inhibition of dimaprit action although the inhibition by the H2-antagonists was not of the surmountable type. Atropine inhibited gastric secretion stimulated by methacholine and pentagastrin more strongly than that stimulated by dimaprit. It is concluded that YM-11170 is a competitive antagonist of dimaprit-induced gastric secretion in vivo and that the activity of the H2-antagonists in blocking gastric H2-receptors may reflect their inhibitory effect on the acid response to pentagastrin and methacholine. |
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AbstractList | The antisecretory property of YM-11170 was compared with that of cimetidine and atropine in the Heidenhain pouch dog. YM-11170 inhibited competitively dimaprit-induced gastric acid secretion in doses of 33 and 100 nmol/kg per h and its antisecretory potency was 148 times more pronounced than that of cimetidine. The secretory action of pentagastrin and methacholine was also inhibited by YM-11170 and cimetidine with doses similar to those required for the inhibition of dimaprit action although the inhibition by the H2-antagonists was not of the surmountable type. Atropine inhibited gastric secretion stimulated by methacholine and pentagastrin more strongly than that stimulated by dimaprit. It is concluded that YM-11170 is a competitive antagonist of dimaprit-induced gastric secretion in vivo and that the activity of the H2-antagonists in blocking gastric H2-receptors may reflect their inhibitory effect on the acid response to pentagastrin and methacholine. |
Author | Takagi, T Takeda, M Maeno, H |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6137398$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Animals Atropine - pharmacology Cimetidine - pharmacology Dimaprit Dogs Famotidine Gastric Acid - metabolism Gastric Mucosa - drug effects Gastric Mucosa - metabolism Histamine H2 Antagonists - pharmacology Kinetics Male Methacholine Chloride Methacholine Compounds - pharmacology Pentagastrin - pharmacology Thiazoles - pharmacology Thiourea - pharmacology |
Title | Kinetics of antisecretory action of a new H2-antagonist, YM-11170, in conscious dogs |
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