Allelic Differences in the Serotonin Transporter-Linked Polymorphic Region in Geriatric Depression
Previous studies have examined the role of genetic variations in the serotonin transporter-linked polymorphic region (5HTTLPR) in affective disorders. The authors studied 182 older depressed subjects and 107 elderly control subjects and obtained DNA for genotyping at the 5HTTLPR. There were no signi...
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Published in | The American journal of geriatric psychiatry Vol. 10; no. 2; pp. 185 - 191 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.03.2002
Elsevier Limited |
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Abstract | Previous studies have examined the role of genetic variations in the serotonin transporter-linked polymorphic region (5HTTLPR) in affective disorders. The authors studied 182 older depressed subjects and 107 elderly control subjects and obtained DNA for genotyping at the 5HTTLPR. There were no significant differences in allele frequencies generally or for number of short alleles for the group as a whole, but interesting gender effects emerged. Among men, 23% of depressed men had two short alleles, compared with only 5% of control subjects. Among women, 67% of depressed women with more than one episode had at least one short allele, compared with 41% of single-episode female patients. Also, 74% of women with a positive family history of psychiatric illness in any female relative had at least one short allele, whereas 53% had at least one short allele who did not have such a family history. Our results add to the literature linking this gene to affective illness. The negative association of allele frequency and depression may be related to the relatively small sample size. The findings raise the possibility that this genetic locus may exert differential effects based on gender, increasing risk in men, and increasing risk of recurrence in women. |
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AbstractList | Previous studies have examined the role of genetic variations in the serotonin transporter-linked polymorphic region (5HTTLPR) in affective disorders. The authors studied 182 older depressed subjects and 107 elderly control subjects and obtained DNA for genotyping at the 5HTTLPR. There were no significant differences in allele frequencies generally or for number of short alleles for the group as a whole, but interesting gender effects emerged. Among men, 23% of depressed men had two short alleles, compared with only 5% of control subjects. Among women, 67% of depressed women with more than one episode had at least one short allele, compared with 41% of single-episode female patients. Also, 74% of women with a positive family history of psychiatric illness in any female relative had at least one short allele, whereas 53% had at least one short allele who did not have such a family history. Our results add to the literature linking this gene to affective illness. The negative association of allele frequency and depression may be related to the relatively small sample size. The findings raise the possibility that this genetic locus may exert differential effects based on gender, increasing risk in men, and increasing risk of recurrence in women. |
Author | Siegler, Ilene C. Hays, Judith C. Svenson, Ingrid Steffens, David C. Flint, Elizabeth P. Levy, Robert M. Marchuk, Douglas A. Krishnan, K. Ranga Rama |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11925279$$D View this record in MEDLINE/PubMed |
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Snippet | Previous studies have examined the role of genetic variations in the serotonin transporter-linked polymorphic region (5HTTLPR) in affective disorders. The... |
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SubjectTerms | Aged Alleles Carrier Proteins - genetics Cross-Sectional Studies Depressive Disorder - genetics Depressive Disorder - psychology Female Humans Longitudinal Studies Male Membrane Glycoproteins - genetics Membrane Transport Proteins Nerve Tissue Proteins Polymorphism, Genetic - genetics Prospective Studies Psychiatric Status Rating Scales Serotonin Plasma Membrane Transport Proteins Sex Factors |
Title | Allelic Differences in the Serotonin Transporter-Linked Polymorphic Region in Geriatric Depression |
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