Pathomechanism of Leukoaraiosis: A Molecular Bridge Between the Genetic, Biochemical, and Clinical Processes (a Mitochondrial Hypothesis)

• Published in: Neuromolecular medicine Vol. 9; no. 1; pp. 21 - 34
• Main Author: Szolnoki, Zoltán
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 2007
• Subjects: Apolipoprotein E2 - genetics; Apolipoprotein E4 - genetics; Brain; Brain - blood supply; Brain - metabolism; Brain - physiopathology; Cytoskeleton - pathology; Energy Metabolism; Humans; Leukoaraiosis - genetics; Leukoaraiosis - metabolism; Leukoaraiosis - pathology; Leukoaraiosis - physiopathology; Medical imaging; Medical research; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Methylenetetrahydrofolate Reductase (NADPH2) - metabolism; Mitochondria - physiology; Mutation; Myelin Basic Protein - metabolism; Myelin Sheath - pathology; Neuroglia - pathology; Oligodendroglia - metabolism; Protein Transport; Renin - genetics; Renin - metabolism

Ischemic demyelination in the white matter of the brain is a frequent clinical entity. In neuroimaging terms, it is referred to as leukoaraiosis (LA). LA can reflect a broad public health problem, which is caused by a cognitive impairment ranging from mild slowness of thinking to full-blown subcorti...