Differential Alteration in Expression of Striatal GABAAR Subunits in Mouse Models of Huntington’s Disease

• Published in: Frontiers in molecular neuroscience Vol. 10; p. 198
• Main Authors: Du, Zhuowei, Tertrais, Margot, Courtand, Gilles, Leste-Lasserre, Thierry, Cardoit, Laura, Masmejean, Frédérique, Halgand, Christophe, Cho, Yoon H., Garret, Maurice
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 20.06.2017; Frontiers Media S.A
• Subjects: Age; Animal cognition; Animal models; Cell membranes; Cognitive ability; Dopamine; Experiments; Forebrain; GABAA receptor; Gene expression; Gephyrin; HdhQ111; Huntington's disease; Interneurons; Labeling; Neostriatum; Neurodegenerative diseases; Neurons; Neuroscience; Neurosciences; Neurotransmission; Parvalbumin; Proteins; R6/1 mouse model; Rodents; striatum; synapse; Synaptic plasticity; Synaptogenesis; Transgenic mice; γ-Aminobutyric acid A receptors; France

Huntington’s disease (HD) is a neurodegenerative disorder characterized by progressive motor symptoms that are preceded by cognitive deficits and is considered as a disorder that primarily affects forebrain striatal neurons. To gain a better understanding of the molecular and cellular mechanisms ass...