Downregulation of HTRA1 Promotes EMT and Anoikis Resistance in Colorectal Cancer via Activation of Hippo/YAP1 Pathway by Facilitating LATS2 Degradation - Jiang, Zhihang; Li, Xiaoqing; Liu, Fuqiang; Li, Junfeng; Yang, Kun; Xu, Shuman; Jiang, Zheng (Molecular carcinogenesis, 2025)
Keywords: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Anoikis; Anoikis - genetics; Cell Line, Tumor; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Down-Regulation; Epithelial-Mesenchymal Transition - genetics; Female; Gene Expression Regulation, Neoplastic; High-Temperature Requirement A Serine Peptidase 1 - genetics; High-Temperature Requirement A Serine Peptidase 1 - metabolism; Hippo Signaling Pathway; Hippo/YAP1 pathway; HTRA1; Humans; Kinases; LATS2; Male; Metastases; Metastasis; Mice; Mice, Nude; Middle Aged; Nuclear transport; Phosphorylation; Prognosis; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Proteolysis; Serine proteinase; Signal Transduction; Temperature requirements; Therapeutic targets; Transcription Factors - genetics; Transcription Factors - metabolism; Tumor suppressor genes; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Tumors; YAP-Signaling Proteins; Yes-associated protein; HTRA1; Hippo/YAP1 pathway; anoikis; LATS2; colorectal cancer