Lewis Acid Catalyzed Cycloaddition of Bicyclobutanes with Ynamides for the Synthesis of Polysubstituted 2‐Amino‐bicyclo[2.1.1]hexenes

• Published in: Angewandte Chemie International Edition Vol. 63; no. 32; pp. e202405781 - n/a
• Main Authors: Hu, Qian‐Qian, Wang, Liu‐Yang, Chen, Xing‐Hao, Geng, Ze‐Xiang, Chen, Jie, Zhou, Ling
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 05.08.2024
• Subjects: Bicyclic compounds; Chemistry; Chemistry, Multidisciplinary; Cycloaddition; Lewis acid; Physical Sciences; Science & Technology; Strain release; Ynamides; Lewis acid; Cycloaddition; Strain release; STRAIN-RELEASE; Ynamides; CONSTRUCTION; Bicyclic compounds; 2-PI+2-SIGMA CYCLOADDITIONS

Synthesis of bicyclic scaffolds has gained significant attention in drug discovery due to their potential to mimic benzene bioisosteres. Here, we present a mild and scalable Sc(OTf)3‐catalyzed [3+2] cycloaddition of bicyclo[1.1.0]butanes (BCBs) with ynamides, yielding a diverse array of polysubstitu...