TOE1 deadenylase inhibits gastric cancer cell proliferation by regulating cell cycle progression

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 1; p. 130736
• Main Authors: Sun, Xiao-Lin, Song, Huan-Xi, Li, Jia-Hui, Liu, Yi-Jin, Wang, Xin-Ya, Zhang, Li-Na
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2025
• Subjects: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation; Deadenylase; Gastric cancer; Gene Expression Regulation, Neoplastic; Humans; p21; p53; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; TOE1; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; TOE1; Deadenylase; Gastric cancer; p21; Cell cycle; p53

TOE1, also known as hCaf1z, belongs to the DEDD superfamily of deadenylases and a newly identified isoenzyme of hCaf1 deadenylases. Previous research has demonstrated that TOE1 has deadenylase activity, which can catalyze the degradation of poly(A) substrates and interact with hCcr4d to form the unc...