Gene expression, levels and polymorphism (Ala16Val) of mitochondrial superoxide dismutase in tuberculosis patients of Rajasthan

• Published in: Microbes and infection Vol. 25; no. 4; p. 105075
• Main Authors: Gauba, Kavya, Gupta, Shruti, Shekhawat, Jyoti, Dutt, Naveen, Yadav, Dharmveer, Nag, Vijaya Lakshmi, Rao, Mahadev, Sharma, Praveen, Banerjee, Mithu
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.05.2023
• Subjects: Expression; Gene Expression; Gene polymorphism; Genotype; Humans; India; Polymorphism, Genetic; Polymorphism, Single Nucleotide; RNA, Messenger; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Superoxide dismutase 2; Tuberculosis; Tuberculosis - genetics; India; Tuberculosis; Expression; Gene polymorphism; Superoxide dismutase 2

Infectious diseases cause redox imbalance and oxidative stress (OS) in host. Superoxide Dismutases(SOD) decrease this OS. SOD2 gene polymorphism can influence the expression and levels of enzyme. To investigate the association of genetic polymorphism of MnSOD with enzyme levels and mRNA expression i...