Gene expression, levels and polymorphism (Ala16Val) of mitochondrial superoxide dismutase in tuberculosis patients of Rajasthan
Infectious diseases cause redox imbalance and oxidative stress (OS) in host. Superoxide Dismutases(SOD) decrease this OS. SOD2 gene polymorphism can influence the expression and levels of enzyme. To investigate the association of genetic polymorphism of MnSOD with enzyme levels and mRNA expression i...
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| Published in | Microbes and infection Vol. 25; no. 4; p. 105075 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Masson SAS
01.05.2023
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| Abstract | Infectious diseases cause redox imbalance and oxidative stress (OS) in host. Superoxide Dismutases(SOD) decrease this OS. SOD2 gene polymorphism can influence the expression and levels of enzyme.
To investigate the association of genetic polymorphism of MnSOD with enzyme levels and mRNA expression in TB patients.
A total of 87 TB patients and 85 healthy individuals participated in the study. The serum SOD2 levels were measured by ELISA. Gene polymorphism was analysed using PCR-RFLP with BsaW1 as the restriction enzyme. Expression was studied by Real-TimePCR. Statistical significance was determined using the Mann–Whitney, Chi-square and Kruskal–Wallis tests and p value < 0.05 was considered statistically significant.
The median(IQR) serum SOD2 levels of TB patients were lower than those of healthy subjects (4.64(6.48) vs 11.35(20.36)ng/mL respectively,p < 0.001). SOD2 expression was significantly down-regulated in TB patients with a fold change value of 0.312. The Val/Val genotype was higher in the patient group than healthy subjects (36.8% vs 23.5%). However, the difference observed between serum SOD2 levels and mRNA expression in the different genotypes were statistically non-significant.
Significant difference was found between levels and expression of SOD2 in TB patients and healthy controls, but not for SOD2 gene polymorphism. |
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| AbstractList | Infectious diseases cause redox imbalance and oxidative stress (OS) in host. Superoxide Dismutases(SOD) decrease this OS. SOD2 gene polymorphism can influence the expression and levels of enzyme.BACKGROUNDInfectious diseases cause redox imbalance and oxidative stress (OS) in host. Superoxide Dismutases(SOD) decrease this OS. SOD2 gene polymorphism can influence the expression and levels of enzyme.To investigate the association of genetic polymorphism of MnSOD with enzyme levels and mRNA expression in TB patients.AIMTo investigate the association of genetic polymorphism of MnSOD with enzyme levels and mRNA expression in TB patients.A total of 87 TB patients and 85 healthy individuals participated in the study. The serum SOD2 levels were measured by ELISA. Gene polymorphism was analysed using PCR-RFLP with BsaW1 as the restriction enzyme. Expression was studied by Real-TimePCR. Statistical significance was determined using the Mann-Whitney, Chi-square and Kruskal-Wallis tests and p value < 0.05 was considered statistically significant.METHODSA total of 87 TB patients and 85 healthy individuals participated in the study. The serum SOD2 levels were measured by ELISA. Gene polymorphism was analysed using PCR-RFLP with BsaW1 as the restriction enzyme. Expression was studied by Real-TimePCR. Statistical significance was determined using the Mann-Whitney, Chi-square and Kruskal-Wallis tests and p value < 0.05 was considered statistically significant.The median(IQR) serum SOD2 levels of TB patients were lower than those of healthy subjects (4.64(6.48) vs 11.35(20.36)ng/mL respectively,p < 0.001). SOD2 expression was significantly down-regulated in TB patients with a fold change value of 0.312. The Val/Val genotype was higher in the patient group than healthy subjects (36.8% vs 23.5%). However, the difference observed between serum SOD2 levels and mRNA expression in the different genotypes were statistically non-significant.RESULTSThe median(IQR) serum SOD2 levels of TB patients were lower than those of healthy subjects (4.64(6.48) vs 11.35(20.36)ng/mL respectively,p < 0.001). SOD2 expression was significantly down-regulated in TB patients with a fold change value of 0.312. The Val/Val genotype was higher in the patient group than healthy subjects (36.8% vs 23.5%). However, the difference observed between serum SOD2 levels and mRNA expression in the different genotypes were statistically non-significant.Significant difference was found between levels and expression of SOD2 in TB patients and healthy controls, but not for SOD2 gene polymorphism.CONCLUSIONSignificant difference was found between levels and expression of SOD2 in TB patients and healthy controls, but not for SOD2 gene polymorphism. Infectious diseases cause redox imbalance and oxidative stress (OS) in host. Superoxide Dismutases(SOD) decrease this OS. SOD2 gene polymorphism can influence the expression and levels of enzyme. To investigate the association of genetic polymorphism of MnSOD with enzyme levels and mRNA expression in TB patients. A total of 87 TB patients and 85 healthy individuals participated in the study. The serum SOD2 levels were measured by ELISA. Gene polymorphism was analysed using PCR-RFLP with BsaW1 as the restriction enzyme. Expression was studied by Real-TimePCR. Statistical significance was determined using the Mann-Whitney, Chi-square and Kruskal-Wallis tests and p value < 0.05 was considered statistically significant. The median(IQR) serum SOD2 levels of TB patients were lower than those of healthy subjects (4.64(6.48) vs 11.35(20.36)ng/mL respectively,p < 0.001). SOD2 expression was significantly down-regulated in TB patients with a fold change value of 0.312. The Val/Val genotype was higher in the patient group than healthy subjects (36.8% vs 23.5%). However, the difference observed between serum SOD2 levels and mRNA expression in the different genotypes were statistically non-significant. Significant difference was found between levels and expression of SOD2 in TB patients and healthy controls, but not for SOD2 gene polymorphism. |
| ArticleNumber | 105075 |
| Author | Nag, Vijaya Lakshmi Dutt, Naveen Banerjee, Mithu Gauba, Kavya Gupta, Shruti Rao, Mahadev Yadav, Dharmveer Shekhawat, Jyoti Sharma, Praveen |
| Author_xml | – sequence: 1 givenname: Kavya surname: Gauba fullname: Gauba, Kavya organization: Department of Biochemistry, All India Institute of Medical Sciences Jodhpur, 342005, India – sequence: 2 givenname: Shruti orcidid: 0000-0002-7435-3496 surname: Gupta fullname: Gupta, Shruti organization: Department of Biochemistry, All India Institute of Medical Sciences Jodhpur, 342005, India – sequence: 3 givenname: Jyoti surname: Shekhawat fullname: Shekhawat, Jyoti organization: Department of Biochemistry, All India Institute of Medical Sciences Jodhpur, 342005, India – sequence: 4 givenname: Naveen surname: Dutt fullname: Dutt, Naveen organization: Department of Pulmonary Medicine, All India Institute of Medical Sciences Jodhpur, 342005, India – sequence: 5 givenname: Dharmveer orcidid: 0000-0002-7109-8039 surname: Yadav fullname: Yadav, Dharmveer organization: Department of Biochemistry, All India Institute of Medical Sciences Jodhpur, 342005, India – sequence: 6 givenname: Vijaya Lakshmi surname: Nag fullname: Nag, Vijaya Lakshmi organization: Department of Microbiology, All India Institute of Medical Sciences Jodhpur, 342005, India – sequence: 7 givenname: Mahadev surname: Rao fullname: Rao, Mahadev organization: Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences Manipal, 576104, India – sequence: 8 givenname: Praveen surname: Sharma fullname: Sharma, Praveen organization: Department of Biochemistry, All India Institute of Medical Sciences Jodhpur, 342005, India – sequence: 9 givenname: Mithu orcidid: 0000-0002-4107-3076 surname: Banerjee fullname: Banerjee, Mithu email: mithu.banerjee.3@gmail.com organization: Department of Biochemistry, All India Institute of Medical Sciences Jodhpur, 342005, India |
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| Keywords | Tuberculosis Expression Gene polymorphism Superoxide dismutase 2 |
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| SubjectTerms | Expression Gene Expression Gene polymorphism Genotype Humans India Polymorphism, Genetic Polymorphism, Single Nucleotide RNA, Messenger Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide dismutase 2 Tuberculosis Tuberculosis - genetics |
| Title | Gene expression, levels and polymorphism (Ala16Val) of mitochondrial superoxide dismutase in tuberculosis patients of Rajasthan |
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