Protein-protein interactions as determinants of operon architecture

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 6; p. 130794
• Main Authors: Bedi, Silky, Rose, S.M., Kaur, Simerpreet, Negi, Preeti, Sinha, Sharmistha
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2025
• Subjects: Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Computational Biology - methods; Escherichia coli - genetics; Escherichia coli - metabolism; FRET; Operon - genetics; Operonic arrangement; Protein Interaction Mapping; Protein Interaction Maps; Protein-protein interactions; Self-assembly; Operonic arrangement; Self-assembly; FRET; Protein-protein interactions

Operons, clusters of genes under a single promoter, often exhibit a specific gene order influencing their physiological function. While functional relatedness is a known factor for clustering, the underlying drivers of gene ordering remain unclear. To investigate this, we analyzed the pdu operon, en...