History of the discovery and development of Biomodulina T (InmunyVital®), a useful immunomodulator with a broad range of clinical applications
•Biomodulina T (InmunyVital®) modulates immune response and inflammation.•Biomodulina T (InmunyVital®) restores immunity and thymus size in children.•Biomodulina T (InmunyVital®) helps control multiple sclerosis.•Biomodulina T (InmunyVital®) reverses B and T cells immunosenescence.•Biomodulina T (In...
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Published in | International immunopharmacology Vol. 119; p. 110167 |
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Format | Journal Article |
Language | English |
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01.06.2023
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Abstract | •Biomodulina T (InmunyVital®) modulates immune response and inflammation.•Biomodulina T (InmunyVital®) restores immunity and thymus size in children.•Biomodulina T (InmunyVital®) helps control multiple sclerosis.•Biomodulina T (InmunyVital®) reverses B and T cells immunosenescence.•Biomodulina T (InmunyVital®) restores immunity in cancer immunotherapy.
Biomodulina T (InmunyVital®) is a thymic factor that modulates immune response and inflammation. Biomodulina T stimulates the differentiation, maturation and proliferation of T cells. Additionally, Biomodulina T improves the ability of T cells to produce cytokines, therefore enhancing T lymphocyte function. Biomodulina T stimulates the thymus gland and, thus, promotes the recovery of normal thymus size in children with thymic hypoplasia and restores the functions of immunosenescent T cells in aging people.
In 1984 Rodriguez Martin RR established the laboratory of Biomodulators, where he created and developed an immunomodulatory thymic factor that he named “Biomodulina T.” The biological activity of Biomodulina T was demonstrated in several studies. An extensive series of preclinical toxicological studies were conducted and these studies demonstrated that Biomodulina T is an active and safe thymic factor.
Clinical trials were conducted with Biomodulina T in patients with immunodeficiency and infections, autoimmune diseases, older adults with recurrent respiratory infections, and cancer.
In 1994, we obtained the approval of Biomodulina T as an immunomodulatory drug.
This article identifies the milestones involved in the development of Biomodulina T. Since its discovery more than 35 years ago, reports show that Biomodulina T is a modulator of immune response and inflammation that is very useful for restoring the immune system in young and elderly people with immunodeficiencies, autoimmune diseases, and infections. Biomodulina T is also useful as an immunotherapeutic agent for improving immune responses in cancer and vaccines, for reversing immunosenescence and for improving healthspan in aging. |
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AbstractList | •Biomodulina T (InmunyVital®) modulates immune response and inflammation.•Biomodulina T (InmunyVital®) restores immunity and thymus size in children.•Biomodulina T (InmunyVital®) helps control multiple sclerosis.•Biomodulina T (InmunyVital®) reverses B and T cells immunosenescence.•Biomodulina T (InmunyVital®) restores immunity in cancer immunotherapy.
Biomodulina T (InmunyVital®) is a thymic factor that modulates immune response and inflammation. Biomodulina T stimulates the differentiation, maturation and proliferation of T cells. Additionally, Biomodulina T improves the ability of T cells to produce cytokines, therefore enhancing T lymphocyte function. Biomodulina T stimulates the thymus gland and, thus, promotes the recovery of normal thymus size in children with thymic hypoplasia and restores the functions of immunosenescent T cells in aging people.
In 1984 Rodriguez Martin RR established the laboratory of Biomodulators, where he created and developed an immunomodulatory thymic factor that he named “Biomodulina T.” The biological activity of Biomodulina T was demonstrated in several studies. An extensive series of preclinical toxicological studies were conducted and these studies demonstrated that Biomodulina T is an active and safe thymic factor.
Clinical trials were conducted with Biomodulina T in patients with immunodeficiency and infections, autoimmune diseases, older adults with recurrent respiratory infections, and cancer.
In 1994, we obtained the approval of Biomodulina T as an immunomodulatory drug.
This article identifies the milestones involved in the development of Biomodulina T. Since its discovery more than 35 years ago, reports show that Biomodulina T is a modulator of immune response and inflammation that is very useful for restoring the immune system in young and elderly people with immunodeficiencies, autoimmune diseases, and infections. Biomodulina T is also useful as an immunotherapeutic agent for improving immune responses in cancer and vaccines, for reversing immunosenescence and for improving healthspan in aging. Biomodulina T (InmunyVital®) is a thymic factor that modulates immune response and inflammation. Biomodulina T stimulates the differentiation, maturation and proliferation of T cells. Additionally, Biomodulina T improves the ability of T cells to produce cytokines, therefore enhancing T lymphocyte function. Biomodulina T stimulates the thymus gland and, thus, promotes the recovery of normal thymus size in children with thymic hypoplasia and restores the functions of immunosenescent T cells in aging people. In 1984 Rodriguez Martin RR established the laboratory of Biomodulators, where he created and developed an immunomodulatory thymic factor that he named "Biomodulina T." The biological activity of Biomodulina T was demonstrated in several studies. An extensive series of preclinical toxicological studies were conducted and these studies demonstrated that Biomodulina T is an active and safe thymic factor. Clinical trials were conducted with Biomodulina T in patients with immunodeficiency and infections, autoimmune diseases, older adults with recurrent respiratory infections, and cancer. In 1994, we obtained the approval of Biomodulina T as an immunomodulatory drug. This article identifies the milestones involved in the development of Biomodulina T. Since its discovery more than 35 years ago, reports show that Biomodulina T is a modulator of immune response and inflammation that is very useful for restoring the immune system in young and elderly people with immunodeficiencies, autoimmune diseases, and infections. Biomodulina T is also useful as an immunotherapeutic agent for improving immune responses in cancer and vaccines, for reversing immunosenescence and for improving healthspan in aging. |
ArticleNumber | 110167 |
Author | Gonzalez Gonzalez, Olivia Rodriguez Gonzalez, Carolina Rodriguez Martin, Roman R. Rodriguez Gonzalez, Rene R. |
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Cites_doi | 10.2139/ssrn.3678181 10.1159/000230959 10.3389/fimmu.2020.606447 10.1073/pnas.56.3.1010 10.1016/j.jare.2018.02.004 10.1038/s41418-019-0462-y 10.1016/j.coph.2010.04.008 10.1084/jem.116.5.773 10.1016/j.clim.2011.03.007 10.1016/j.exger.2021.111497 10.3389/fonc.2022.823287 10.1016/j.exger.2019.110633 |
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Keywords | COVID-19 Multiple sclerosis InmunyVital Immunomodulation Thymic factor Immunotherapy Immunosenescence Thymus factor Biomodulina T T cells |
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References_xml | – volume: 22 start-page: 17 year: 1993 end-page: 23 ident: b0030 article-title: Caracterización fisicoquímica de una fracción de timo. I Aspectos generales publication-title: Rev Cubana Med Militar contributor: fullname: Pelaez Borges – volume: 22 start-page: 72 year: 1988 end-page: 83 ident: b0020 publication-title: Biomoduladores Tímicos. Revisión Bibliográfica. Rev Cubana Farmacia contributor: fullname: Pelaez Borges – volume: 22 start-page: 108 year: 1993 end-page: 111 ident: b0040 article-title: Ensayo de Actividad Biológica de una fracción de Timo publication-title: Biomodulina T. Rev Cubana Med Militar contributor: fullname: Gonzalez Gonzalez – volume: 12 start-page: 823287 year: 2022 ident: b0085 article-title: Thymic Polypeptide Fraction Biomodulina T Decreases Exhausted and Terminally Differentiated EMRA T Cells in Advanced Lung Cancer Patients Treated With Platinum-Based Chemotherapy publication-title: Front. Oncol. contributor: fullname: Saavedra – volume: 27 start-page: 396 year: 2020 end-page: 401 ident: b0005 article-title: The early work on the discovery of the function of the thymus, an interview with Jacques Miller publication-title: Cell Death Differ contributor: fullname: Miller – volume: 140 start-page: 26 year: 2011 end-page: 36 ident: b0035 article-title: Premature aging of the Immune System underlies immunodeficiency in Ataxia-Telangiectasia publication-title: J Clin Immunol contributor: fullname: Last – volume: 15 start-page: 67 year: 2018 Feb end-page: 79 ident: b0050 article-title: Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review publication-title: J. Adv. Res. contributor: fullname: Das – volume: 23 start-page: 31 year: 1994 end-page: 35 ident: b0055 article-title: Tratamiento de la Inmunodeficiencia Selectiva de IgA con Biomodulina T publication-title: Rev Cubana Med Militar contributor: fullname: Pelaez Borges – volume: 8 start-page: 28 year: 2007 end-page: 31 ident: b0070 article-title: Estudio fase II de tratamiento de pacientes con Esclerosis múltiple exacerbante-remitente con Biomodulina T publication-title: Rev Mex Neurociencias contributor: fullname: Marzoa Silva – volume: 124 start-page: 110633 year: 2019 ident: b0075 article-title: Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly publication-title: Exp Gerontol contributor: fullname: Garcia – volume: 44 start-page: 544 year: 1973 end-page: 552 ident: b0045 article-title: Rosette-formation between guinea pig lymphoid cells and rabbit erythrocytes – a possible T-cell marker publication-title: Int Arch Allergy contributor: fullname: Coombs – volume: 11 start-page: 606447 year: 2020 ident: b0090 article-title: Biomodulina T (InmunyVital®) Restores T Cells and Helps Contain COVID-19 publication-title: Front. Immunol. contributor: fullname: Rodriguez Gonzalez – volume: 22 start-page: 72 issue: 2 year: 1988 ident: 10.1016/j.intimp.2023.110167_b0020 publication-title: Biomoduladores Tímicos. Revisión Bibliográfica. Rev Cubana Farmacia contributor: fullname: Rodriguez Martin – ident: 10.1016/j.intimp.2023.110167_b0025 doi: 10.2139/ssrn.3678181 – volume: 44 start-page: 544 year: 1973 ident: 10.1016/j.intimp.2023.110167_b0045 article-title: Rosette-formation between guinea pig lymphoid cells and rabbit erythrocytes – a possible T-cell marker publication-title: Int Arch Allergy doi: 10.1159/000230959 contributor: fullname: Wilson – volume: 11 start-page: 606447 year: 2020 ident: 10.1016/j.intimp.2023.110167_b0090 article-title: Biomodulina T (InmunyVital®) Restores T Cells and Helps Contain COVID-19 publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.606447 contributor: fullname: Rodriguez Martin – volume: 23 start-page: 31 issue: 1 year: 1994 ident: 10.1016/j.intimp.2023.110167_b0055 article-title: Tratamiento de la Inmunodeficiencia Selectiva de IgA con Biomodulina T publication-title: Rev Cubana Med Militar contributor: fullname: Rodriguez Martin – ident: #cr-split#-10.1016/j.intimp.2023.110167_b0015.1 doi: 10.1073/pnas.56.3.1010 – volume: 22 start-page: 17 issue: 1 year: 1993 ident: 10.1016/j.intimp.2023.110167_b0030 article-title: Caracterización fisicoquímica de una fracción de timo. I Aspectos generales publication-title: Rev Cubana Med Militar contributor: fullname: Rodriguez Martin – volume: 15 start-page: 67 issue: 11 year: 2018 ident: 10.1016/j.intimp.2023.110167_b0050 article-title: Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review publication-title: J. Adv. Res. doi: 10.1016/j.jare.2018.02.004 contributor: fullname: Das – volume: 27 start-page: 396 year: 2020 ident: 10.1016/j.intimp.2023.110167_b0005 article-title: The early work on the discovery of the function of the thymus, an interview with Jacques Miller publication-title: Cell Death Differ doi: 10.1038/s41418-019-0462-y contributor: fullname: Miller – ident: 10.1016/j.intimp.2023.110167_b0060 doi: 10.1016/j.coph.2010.04.008 – ident: 10.1016/j.intimp.2023.110167_b0010 doi: 10.1084/jem.116.5.773 – ident: #cr-split#-10.1016/j.intimp.2023.110167_b0015.2 doi: 10.1073/pnas.56.3.1010 – volume: 140 start-page: 26 year: 2011 ident: 10.1016/j.intimp.2023.110167_b0035 article-title: Premature aging of the Immune System underlies immunodeficiency in Ataxia-Telangiectasia publication-title: J Clin Immunol doi: 10.1016/j.clim.2011.03.007 contributor: fullname: Exley – ident: 10.1016/j.intimp.2023.110167_b0080 doi: 10.1016/j.exger.2021.111497 – volume: 8 start-page: 28 issue: 1 year: 2007 ident: 10.1016/j.intimp.2023.110167_b0070 article-title: Estudio fase II de tratamiento de pacientes con Esclerosis múltiple exacerbante-remitente con Biomodulina T publication-title: Rev Mex Neurociencias contributor: fullname: Gamez Morales – volume: 22 start-page: 108 issue: 2 year: 1993 ident: 10.1016/j.intimp.2023.110167_b0040 article-title: Ensayo de Actividad Biológica de una fracción de Timo publication-title: Biomodulina T. Rev Cubana Med Militar contributor: fullname: Rodriguez Martin – volume: 12 start-page: 823287 year: 2022 ident: 10.1016/j.intimp.2023.110167_b0085 article-title: Thymic Polypeptide Fraction Biomodulina T Decreases Exhausted and Terminally Differentiated EMRA T Cells in Advanced Lung Cancer Patients Treated With Platinum-Based Chemotherapy publication-title: Front. Oncol. doi: 10.3389/fonc.2022.823287 contributor: fullname: Suárez – volume: 124 start-page: 110633 year: 2019 ident: 10.1016/j.intimp.2023.110167_b0075 article-title: Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly publication-title: Exp Gerontol doi: 10.1016/j.exger.2019.110633 contributor: fullname: Saavedra – ident: 10.1016/j.intimp.2023.110167_b0065 |
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SubjectTerms | Adjuvants, Immunologic Aged Aging Autoimmune Diseases Biomodulina T Child COVID-19 Humans Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Immunomodulation Immunosenescence Immunotherapy Inflammation InmunyVital Male Multiple sclerosis Neoplasms T cells T-Lymphocytes Thymic factor Thymus factor Thymus Gland |
Title | History of the discovery and development of Biomodulina T (InmunyVital®), a useful immunomodulator with a broad range of clinical applications |
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