Development of a nano-targeting chimera for the degradation of membrane and cytoplasmic proteins

• Published in: Acta biomaterialia Vol. 195; pp. 509 - 521
• Main Authors: Jin, Peipei, Chen, Zhaozheng, Zhang, Ju, Li, Haowen, Wei, Pengfei, Wang, Ziyu, Feng, Qiyu, Wang, Hongyang, Han, Da, Miao, Yanyan
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 15.03.2025
• Subjects: Animals; Aptamer; Aptamers, Nucleotide - chemistry; Aptamers, Nucleotide - pharmacology; Autophagy; Autophagy-lysosome; Cancer therapy; Cell Line, Tumor; Cytoplasm - metabolism; Graphene oxide (GO); Graphite - chemistry; Graphite - pharmacology; Humans; Lysosomes - metabolism; Membrane Proteins - metabolism; Mice; Mice, Nude; Proteasome Endopeptidase Complex - metabolism; Proteolysis; Targeted protein degradation; Ubiquitin-proteasome; Aptamer; Graphene oxide (GO); Autophagy-lysosome; Targeted protein degradation; Cancer therapy; Ubiquitin-proteasome

Various targeted protein degradation (TPD) approaches have been developed to overcome the limitations of traditional drug in eliminating pathogenic proteins by exploiting either the proteasomal or lysosomal pathway. However, there is still a lack of design strategies for TPD that utilize two distinc...