Dose equivalence of midazolam and triazolam. A psychometric study based on flicker sensitivity, reaction time and digit symbol substitution test

• Published in: European journal of clinical pharmacology Vol. 36; no. 2; p. 181
• Main Authors: Sostmann, H J, Sostmann, H, Crevoisier, C, Bircher, J
• Format: Journal Article
• Language: English
• Published: Germany 01.01.1989
• Subjects: Adult; Double-Blind Method; Female; Flicker Fusion - drug effects; Humans; Male; Midazolam - administration & dosage; Midazolam - pharmacology; Perception - drug effects; Psychometrics; Psychomotor Performance - drug effects; Reaction Time - drug effects; Self Concept - drug effects; Sensory Thresholds - drug effects; Triazolam - administration & dosage; Triazolam - pharmacology

The pharmacodynamic potency of oral midazolam, a new ultrashort-acting hypnotic benzodiazepine, has been evaluated relative to a standard dose of triazolam, a well established oral benzodiazepine with a similar pharmacological profile. In a balanced design, double-blind cross-over study 6 healthy vo...