Exportin XPO6 upregulation activates the TLR2/MyD88/NF-κB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes - Wu, Yuting; Gou, Yanni; Wang, Tao; Li, Ping; Li, Yongqiang; Lu, Xing; Li, Weifeng; Liu, Zhifeng (International immunopharmacology, 2024)
Keywords: Active Transport, Cell Nucleus; Animals; COPD; Disease Models, Animal; Female; Humans; Karyopherins - metabolism; Lung - immunology; Lung - metabolism; Lung - pathology; Lung inflammation; Male; Mice; Mice, Inbred C57BL; Monocytes - drug effects; Monocytes - immunology; Monocytes - metabolism; Myeloid Differentiation Factor 88 - metabolism; NF-kappa B - metabolism; NF-κB; Pulmonary Disease, Chronic Obstructive - immunology; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary monocytes; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction; Toll-Like Receptor 2 - genetics; Toll-Like Receptor 2 - metabolism; Toll-like receptors; Up-Regulation; Toll-like receptors; NF-κB; Lung inflammation; Pulmonary monocytes; COPD