Peptide PaDBS1R6 has potent antibacterial activity on clinical bacterial isolates and integrates an immunomodulatory peptide fragment within its sequence

• Published in: Biochimica et biophysica acta. General subjects Vol. 1868; no. 11; p. 130693
• Main Authors: Rezende, Samilla B., Chan, Lai Yue, Oshiro, Karen G.N., Buccini, Danieli F., Leal, Ana Paula Ferreira, Ribeiro, Camila F., Souza, Carolina M., Brandão, Amanda L.O., Gonçalves, Regina M., Cândido, Elizabete S., Macedo, Maria L.R., Craik, David J., Franco, Octávio L., Cardoso, Marlon H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2024
• Subjects: Acinetobacter baumannii - drug effects; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial peptides; Antimicrobial Peptides - chemistry; Antimicrobial Peptides - pharmacology; Biofilms - drug effects; Escherichia coli - drug effects; Humans; Immunomodulatory peptides; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Peptide Fragments - chemistry; Peptide Fragments - pharmacology; Resistant bacteria; Wound healing; 10RMSD; 28MSD; 1AMP; 24PBS; 18MBC; 17MIC; Antibacterial peptides; 7MD; 14LACEN; 16MHB; 22FBS; 2APD; 9PME; 21DMEM; 30IM; 11RMSF; 3NCBI; Immunomodulatory peptides; 12Rg; Wound healing; 6NMR; 8DPC; 15MHA; 13CLSI; 19OD; 26SUV; 27SPR; 31OM; 29MBIC; 23MTT; 25DMSO; 5NO; Resistant bacteria; 4NR; 20CEUA

Resistant infectious diseases caused by gram-negative bacteria are among the most serious worldwide health problems. Antimicrobial peptides (AMPs) have been explored as promising antibacterial, antibiofilm, and anti-infective candidates to address these health challenges. Here we report the potent a...