Variable dependency on BAFF in IgG antibody production during Leishmania infection

• Published in: Parasitology international Vol. 74; p. 101997
• Main Authors: Azuma, Natsuho, Omachi, Satoko, Hanazawa, Wakana, Morimoto, Ayako, Sanjoba, Chizu, Matsumoto, Yoshitsugu, Fujii, Wataru, Goto, Yasuyuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2020
• Subjects: Animals; Antibodies, Protozoan - immunology; Antibody response; Antigens, Protozoan - immunology; B-Cell Activating Factor - genetics; B-Cell Activating Factor - immunology; BAFF; Female; Immunoglobulin G - immunology; Leishmania donovani - immunology; Leishmaniasis; Leishmaniasis - immunology; Mice; Mice, Inbred BALB C; Mice, Knockout; BAFF; Leishmaniasis; Antibody response

B-cell activating factor (BAFF) is known as a cytokine responsible for survival and activation of B cells. However, involvement of the molecule in IgG antibody production during infection remains elusive. In this study, dependency of antibody production in Leishmania infection on BAFF was examined b...