Effect of clonidine on the human acoustic startle reflex
The present study investigated in healthy human volunteers whether clonidine reduced the amplitude of the acoustic startle reflex and whether this effect, if found, was due to an accelerated rate of habituation. Subjects were presented with startle-eliciting noise-bursts after intravenous (iv) infus...
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Published in | Psychopharmacology Vol. 123; no. 4; p. 353 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
01.02.1996
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Abstract | The present study investigated in healthy human volunteers whether clonidine reduced the amplitude of the acoustic startle reflex and whether this effect, if found, was due to an accelerated rate of habituation. Subjects were presented with startle-eliciting noise-bursts after intravenous (iv) infusion of clonidine (1.5 microgram/kg) and saline on separate days. Clonidine significantly reduced the amplitude of the acoustic startle reflex (as indexed by the eyeblink component) relative to the saline treated condition. This effect was neither due to an accelerated rate of habituation of the startle reflex nor to the sedative effect of clonidine. These findings complement an earlier report (Morgan et al. 1993) that yohimbine augments the amplitude of the startle reflex in man. Taken together, the two reports indicate a new model for the clinical investigation of central alpha2 adrenoceptor function in humans. |
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AbstractList | The present study investigated in healthy human volunteers whether clonidine reduced the amplitude of the acoustic startle reflex and whether this effect, if found, was due to an accelerated rate of habituation. Subjects were presented with startle-eliciting noise-bursts after intravenous (iv) infusion of clonidine (1.5 microgram/kg) and saline on separate days. Clonidine significantly reduced the amplitude of the acoustic startle reflex (as indexed by the eyeblink component) relative to the saline treated condition. This effect was neither due to an accelerated rate of habituation of the startle reflex nor to the sedative effect of clonidine. These findings complement an earlier report (Morgan et al. 1993) that yohimbine augments the amplitude of the startle reflex in man. Taken together, the two reports indicate a new model for the clinical investigation of central alpha2 adrenoceptor function in humans. |
Author | Checkley, S A Corr, P J Kumari, V Cotter, P Gray, J A |
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SubjectTerms | Acoustic Stimulation Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - pharmacology Adult Affect - drug effects Attention - drug effects Blood Pressure - drug effects Clonidine - administration & dosage Clonidine - pharmacology Cross-Over Studies Double-Blind Method Female Habituation, Psychophysiologic Humans Infusions, Intravenous Male Reflex, Startle - drug effects |
Title | Effect of clonidine on the human acoustic startle reflex |
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