Atorvastatin rescues pulmonary artery hypertension by inhibiting the AKT/ERK-dependent PDGF-BB/HIF-1α axis

• Published in: Panminerva medica Vol. 66; no. 1; p. 4
• Main Authors: Chen, Jianfei, Song, Mingbao, Qian, Dehui, Liu, Linqiong, Yang, Kun, Shou, Yunfeng, Zhao, Hanru, Zhang, Li
• Format: Journal Article
• Language: English
• Published: Italy 01.03.2024
• Subjects: Animals; Atorvastatin - pharmacology; Atorvastatin - therapeutic use; Becaplermin; Humans; Hypertension; Hypoxia; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats

The aim of this study is to explore the role of atorvastatin in rescuing pulmonary artery hypertension (PAH) by inhibiting the AKT/ERK-dependent PDGF-BB/HIF-1α axis. PAH model in rats was established by MCT induction, followed by Atorvastatin intervention. Pulmonary hemodynamic measurement and pulmo...