Phosphorylation of the prokaryotic histone-like protein H-NS modulates bacterial virulence in Salmonella Typhimurium

• Published in: Microbiological research Vol. 292; p. 128041
• Main Authors: Wang, Ying, Ge, Jinli, Xian, Wei, Tang, Zhiheng, Xue, Baoshuai, Yu, Jingchen, Yao, Yu-Feng, Liu, Huwei, Qiu, Jiazhang, Liu, Xiaoyun
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.03.2025
• Subjects: Bacterial effectors; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Gene Expression Regulation, Bacterial; H-NS; Histones - metabolism; Humans; Phosphorylation; Protein Processing, Post-Translational; Salmonella Infections - microbiology; Salmonella typhimurium - genetics; Salmonella typhimurium - metabolism; Salmonella typhimurium - pathogenicity; Samonella typhimurium; Type III Secretion Systems - genetics; Type III Secretion Systems - metabolism; Virulence; Virulence - genetics; Bacterial effectors; Phosphorylation; H-NS; Virulence; Samonella typhimurium

H-NS is a prokaryotic histone-like protein that binds to bacterial chromosomal DNA with important regulatory roles in gene expression. Unlike histone proteins, hitherto post-translational modifications of H-NS are still largely uncharacterized, especially in bacterial pathogens. Salmonella Typhimuri...