Pharmacokinetics and safety of salbutamol/ambroxol fixed-dose combination granules in healthy Chinese subjects

• Published in: International journal of clinical pharmacology and therapeutics Vol. 56; no. 12; pp. 597 - 603
• Main Authors: Wang, Yan, Lu, Jin, Li, Tengfei, Zhao, Shunbo, Yang, Wen, Liu, Lingye, Shi, Xing, Michael, Mtalimanja, Ding, Li
• Format: Journal Article
• Language: English
• Published: Germany Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG 01.12.2018
• Subjects: Administration, Oral; Adrenergic beta-2 Receptor Agonists - administration & dosage; Adrenergic beta-2 Receptor Agonists - adverse effects; Adrenergic beta-2 Receptor Agonists - blood; Adrenergic beta-2 Receptor Agonists - pharmacokinetics; Adult; Albuterol - administration & dosage; Albuterol - adverse effects; Albuterol - blood; Albuterol - pharmacokinetics; Ambroxol - administration & dosage; Ambroxol - adverse effects; Ambroxol - blood; Ambroxol - pharmacokinetics; China; Chromatography, Liquid; Dosage Forms; Drug Administration Schedule; Drug dosages; Expectorants - administration & dosage; Expectorants - adverse effects; Expectorants - pharmacokinetics; Female; Gender differences; Healthy Volunteers; Humans; Laboratories; Male; Models, Biological; Pharmaceuticals; Pharmacokinetics; Prescription drugs; Quality control; Tandem Mass Spectrometry; Young Adult; China

The aim of the study was to investigate the pharmacokinetics and tolerability of salbutamol/ambroxol fixed-dose combination granules following single and multiple dosing in healthy Chinese subjects. This was a randomized, open-label, two-period, one-sequence study (n = 12). Each subject received a s...