Role of T cells in the pathogenesis of systemic lupus erythematous: Focus on immunometabolism dysfunctions
•T cells are implicated in developing SLE disease.•Metabolic pathways are implicated in fate and function of T cells.•Metabolic pathways are dysregulated in SLE T cells.•Developing drugs to regulate T cell metabolism could be a promising therapeutic approach for SLE patients. Evidence demonstrates t...
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Published in | International immunopharmacology Vol. 119; p. 110246 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Netherlands
Elsevier B.V
01.06.2023
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Abstract | •T cells are implicated in developing SLE disease.•Metabolic pathways are implicated in fate and function of T cells.•Metabolic pathways are dysregulated in SLE T cells.•Developing drugs to regulate T cell metabolism could be a promising therapeutic approach for SLE patients.
Evidence demonstrates that T cells are implicated in developing SLE, and each of them dominantly uses distinct metabolic pathways. Indeed, intracellular enzymes and availability of specific nutrients orchestrate fate of T cells and lead to differentiation of regulatory T cells (Treg), memory T cells, helper T cells, and effector T cells. The function of T cells in inflammatory and autoimmune responses is determined by metabolic processes and activity of their enzymes. Several studies were conducted to determine metabolic abnormalities in SLE patients and clarify how these modifications could control the functions of the involved T cells. Metabolic pathways such as glycolysis, mitochondrial pathways, oxidative stress, mTOR pathway, fatty acid and amino acid metabolisms are dysregulated in SLE T cells. Moreover, immunosuppressive drugs used in treating autoimmune diseases, including SLE, could affect immunometabolism. Developing drugs to regulate autoreactive T cell metabolism could be a promising therapeutic approach for SLE treatment. Accordingly, increased knowledge about metabolic processes paves the way to understanding SLE pathogenesis better and introduces novel therapeutic options for SLE treatment. Although monotherapy with metabolic pathways modulators might not be sufficient to prevent autoimmune disease, they may be an ideal adjuvant to reduce administration doses of immunosuppressive drugs, thus reducing drug-associated adverse effects. This review summarized emerging data about T cells that are involved in SLE pathogenesis, focusing on immunometabolism dysregulation and how these modifications could affect the disease development. |
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AbstractList | Evidence demonstrates that T cells are implicated in developing SLE, and each of them dominantly uses distinct metabolic pathways. Indeed, intracellular enzymes and availability of specific nutrients orchestrate fate of T cells and lead to differentiation of regulatory T cells (Treg), memory T cells, helper T cells, and effector T cells. The function of T cells in inflammatory and autoimmune responses is determined by metabolic processes and activity of their enzymes. Several studies were conducted to determine metabolic abnormalities in SLE patients and clarify how these modifications could control the functions of the involved T cells. Metabolic pathways such as glycolysis, mitochondrial pathways, oxidative stress, mTOR pathway, fatty acid and amino acid metabolisms are dysregulated in SLE T cells. Moreover, immunosuppressive drugs used in treating autoimmune diseases, including SLE, could affect immunometabolism. Developing drugs to regulate autoreactive T cell metabolism could be a promising therapeutic approach for SLE treatment. Accordingly, increased knowledge about metabolic processes paves the way to understanding SLE pathogenesis better and introduces novel therapeutic options for SLE treatment. Although monotherapy with metabolic pathways modulators might not be sufficient to prevent autoimmune disease, they may be an ideal adjuvant to reduce administration doses of immunosuppressive drugs, thus reducing drug-associated adverse effects. This review summarized emerging data about T cells that are involved in SLE pathogenesis, focusing on immunometabolism dysregulation and how these modifications could affect the disease development. •T cells are implicated in developing SLE disease.•Metabolic pathways are implicated in fate and function of T cells.•Metabolic pathways are dysregulated in SLE T cells.•Developing drugs to regulate T cell metabolism could be a promising therapeutic approach for SLE patients. Evidence demonstrates that T cells are implicated in developing SLE, and each of them dominantly uses distinct metabolic pathways. Indeed, intracellular enzymes and availability of specific nutrients orchestrate fate of T cells and lead to differentiation of regulatory T cells (Treg), memory T cells, helper T cells, and effector T cells. The function of T cells in inflammatory and autoimmune responses is determined by metabolic processes and activity of their enzymes. Several studies were conducted to determine metabolic abnormalities in SLE patients and clarify how these modifications could control the functions of the involved T cells. Metabolic pathways such as glycolysis, mitochondrial pathways, oxidative stress, mTOR pathway, fatty acid and amino acid metabolisms are dysregulated in SLE T cells. Moreover, immunosuppressive drugs used in treating autoimmune diseases, including SLE, could affect immunometabolism. Developing drugs to regulate autoreactive T cell metabolism could be a promising therapeutic approach for SLE treatment. Accordingly, increased knowledge about metabolic processes paves the way to understanding SLE pathogenesis better and introduces novel therapeutic options for SLE treatment. Although monotherapy with metabolic pathways modulators might not be sufficient to prevent autoimmune disease, they may be an ideal adjuvant to reduce administration doses of immunosuppressive drugs, thus reducing drug-associated adverse effects. This review summarized emerging data about T cells that are involved in SLE pathogenesis, focusing on immunometabolism dysregulation and how these modifications could affect the disease development. |
ArticleNumber | 110246 |
Author | Saadh, Mohamed J. Mousavi, Mohammad Javad Karami, Jafar Masoumi, Maryam Kazemi, Khadijehsadat Noroozi, Negar Khorramdelazad, Hossein |
Author_xml | – sequence: 1 givenname: Mohamed J. surname: Saadh fullname: Saadh, Mohamed J. organization: Department of Basic Sciences, Faculty of Pharmacy, Middle East University, Amman, Jordan – sequence: 2 givenname: Khadijehsadat surname: Kazemi fullname: Kazemi, Khadijehsadat organization: Faculty of Nursing, Golestan University of Medical Sciences, Golestan, Iran – sequence: 3 givenname: Hossein surname: Khorramdelazad fullname: Khorramdelazad, Hossein organization: Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran – sequence: 4 givenname: Mohammad Javad surname: Mousavi fullname: Mousavi, Mohammad Javad organization: Department of Hematology, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran – sequence: 5 givenname: Negar surname: Noroozi fullname: Noroozi, Negar organization: Student Research and Technology Committee, Bushehr University of Medical Sciences, Bushehr, Iran – sequence: 6 givenname: Maryam surname: Masoumi fullname: Masoumi, Maryam email: m.masoumiy@gmail.com organization: Clinical Research Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran – sequence: 7 givenname: Jafar orcidid: 0000-0002-2554-1669 surname: Karami fullname: Karami, Jafar email: jafar.karami@khomeinums.ac.ir organization: Molecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37148769$$D View this record in MEDLINE/PubMed |
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Keywords | Autoimmunity Systemic lupus erythematous Immunometabolism SLE T cell |
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Snippet | •T cells are implicated in developing SLE disease.•Metabolic pathways are implicated in fate and function of T cells.•Metabolic pathways are dysregulated in... Evidence demonstrates that T cells are implicated in developing SLE, and each of them dominantly uses distinct metabolic pathways. Indeed, intracellular... |
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SubjectTerms | Autoimmune Diseases Autoimmunity Humans Immunometabolism Immunosuppressive Agents Lupus Erythematosus, Systemic Oxidative Stress Skin Diseases SLE T cell Systemic lupus erythematous T-Lymphocytes, Helper-Inducer T-Lymphocytes, Regulatory |
Title | Role of T cells in the pathogenesis of systemic lupus erythematous: Focus on immunometabolism dysfunctions |
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