A UNIFIED FRAMEWORK FOR VARIANCE COMPONENT ESTIMATION WITH SUMMARY STATISTICS IN GENOME-WIDE ASSOCIATION STUDIES

• Published in: The annals of applied statistics Vol. 11; no. 4; p. 2027
• Main Author: Zhou, Xiang
• Format: Journal Article
• Language: English
• Published: United States 01.12.2017
• Subjects: MINQUE; variance component; Genome-wide association studies; summary statistics; method of moments; linear mixed model

Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, the standard method for estimating variance components in LMMs-the restricted maximum likelihood estimation method (REML)-suffers from several important drawbacks: REML requires individual-lev...