From Peptides to Receptors
— In the 1960s and 1970s, the Institute of Chemistry of Natural Compounds developed a topochemical approach for designing new biologically active peptide compounds, the applicability of which to the creation of inhibitors and effective substrates of proteolytic enzymes was shown by the author of thi...
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Published in | Russian journal of bioorganic chemistry Vol. 49; no. 3; pp. 417 - 421 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Moscow
Pleiades Publishing
01.06.2023
Springer Nature B.V |
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Abstract | —
In the 1960s and 1970s, the Institute of Chemistry of Natural Compounds developed a topochemical approach for designing new biologically active peptide compounds, the applicability of which to the creation of inhibitors and effective substrates of proteolytic enzymes was shown by the author of this review under the direct supervision of V.T. Ivanov. The next task was to establish the conformation of protein neurotoxins from snake venoms and to study the topography of their binding to the target, the nicotinic acetylcholine receptor (nAChR) from the electric organ of the
Torpedo marmorata
ray. With selectively labeled derivatives containing one fluorescent or spin label on established amino acid residues, neurotoxin residues in contact with nAChR were identified for the first time. Later, in collaboration with the laboratory of V.T. Ivanov, new analogs of α-conotoxins (peptide neurotoxins from venomous
Conus
mollusks), were synthesized including their photoactivated derivatives, which showed the participation of all
Torpedo
nAChR subunits in the binding of α-conotoxins. In the final part, the review briefly presents the recent achievements of the Department of Molecular Neuroimmune Signaling (headed by V.I. Tsetlin) concerning the isolation and synthesis of new peptide and protein neurotoxins and the study of how they work. |
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AbstractList | —
In the 1960s and 1970s, the Institute of Chemistry of Natural Compounds developed a topochemical approach for designing new biologically active peptide compounds, the applicability of which to the creation of inhibitors and effective substrates of proteolytic enzymes was shown by the author of this review under the direct supervision of V.T. Ivanov. The next task was to establish the conformation of protein neurotoxins from snake venoms and to study the topography of their binding to the target, the nicotinic acetylcholine receptor (nAChR) from the electric organ of the
Torpedo marmorata
ray. With selectively labeled derivatives containing one fluorescent or spin label on established amino acid residues, neurotoxin residues in contact with nAChR were identified for the first time. Later, in collaboration with the laboratory of V.T. Ivanov, new analogs of α-conotoxins (peptide neurotoxins from venomous
Conus
mollusks), were synthesized including their photoactivated derivatives, which showed the participation of all
Torpedo
nAChR subunits in the binding of α-conotoxins. In the final part, the review briefly presents the recent achievements of the Department of Molecular Neuroimmune Signaling (headed by V.I. Tsetlin) concerning the isolation and synthesis of new peptide and protein neurotoxins and the study of how they work. Abstract— In the 1960s and 1970s, the Institute of Chemistry of Natural Compounds developed a topochemical approach for designing new biologically active peptide compounds, the applicability of which to the creation of inhibitors and effective substrates of proteolytic enzymes was shown by the author of this review under the direct supervision of V.T. Ivanov. The next task was to establish the conformation of protein neurotoxins from snake venoms and to study the topography of their binding to the target, the nicotinic acetylcholine receptor (nAChR) from the electric organ of the Torpedo marmorata ray. With selectively labeled derivatives containing one fluorescent or spin label on established amino acid residues, neurotoxin residues in contact with nAChR were identified for the first time. Later, in collaboration with the laboratory of V.T. Ivanov, new analogs of α-conotoxins (peptide neurotoxins from venomous Conus mollusks), were synthesized including their photoactivated derivatives, which showed the participation of all Torpedo nAChR subunits in the binding of α-conotoxins. In the final part, the review briefly presents the recent achievements of the Department of Molecular Neuroimmune Signaling (headed by V.I. Tsetlin) concerning the isolation and synthesis of new peptide and protein neurotoxins and the study of how they work. Abstract—In the 1960s and 1970s, the Institute of Chemistry of Natural Compounds developed a topochemical approach for designing new biologically active peptide compounds, the applicability of which to the creation of inhibitors and effective substrates of proteolytic enzymes was shown by the author of this review under the direct supervision of V.T. Ivanov. The next task was to establish the conformation of protein neurotoxins from snake venoms and to study the topography of their binding to the target, the nicotinic acetylcholine receptor (nAChR) from the electric organ of the Torpedo marmorata ray. With selectively labeled derivatives containing one fluorescent or spin label on established amino acid residues, neurotoxin residues in contact with nAChR were identified for the first time. Later, in collaboration with the laboratory of V.T. Ivanov, new analogs of α-conotoxins (peptide neurotoxins from venomous Conus mollusks), were synthesized including their photoactivated derivatives, which showed the participation of all Torpedo nAChR subunits in the binding of α-conotoxins. In the final part, the review briefly presents the recent achievements of the Department of Molecular Neuroimmune Signaling (headed by V.I. Tsetlin) concerning the isolation and synthesis of new peptide and protein neurotoxins and the study of how they work. |
Author | Tsetlin, V. I. |
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Cites_doi | 10.1073/pnas.74.3.971 10.1046/j.1432-1327.2001.02272.x 10.3390/pharmaceutics13122065 10.1002/ange.19690811404 10.1021/acs.jmedchem.0c00975 10.1038/srep36848 10.1002/psc.2796 10.1016/0014-5793(79)80692-4 10.3390/toxins10010034 10.1111/j.1432-1033.1976.tb11150.x 10.1038/nsmb951 10.1038/s41598-020-71404-0 10.3390/biomedicines8080249 10.1002/anie.201411408 10.1002/1873-3468.12884 10.1016/j.biochi.2021.12.013 10.3233/JAD-2010-091474 10.1111/j.1432-1033.1988.tb14437.x 10.1038/s41467-022-32174-7 10.1111/j.1432-1033.1979.tb12899.x 10.3390/biomedicines10092110 10.1023/A:1011319101676 10.1124/mol.119.117713 10.1042/BCJ20180909 10.1073/pnas.92.16.7282 10.1007/s00018-021-03985-6 |
ContentType | Journal Article |
Copyright | The Author(s) 2023. ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2023, Vol. 49, No. 3, pp. 417–421. © The Author(s), 2023. This article is an open access publication. Russian Text © The Author(s), 2023, published in Bioorganicheskaya Khimiya, 2023, Vol. 49, No. 3, pp. 224–228. The Author(s) 2023. ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2023, Vol. 49, No. 3, pp. 417–421. © The Author(s), 2023. This article is an open access publication. Russian Text © The Author(s), 2023, published in Bioorganicheskaya Khimiya, 2023, Vol. 49, No. 3, pp. 224–228. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: The Author(s) 2023. ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2023, Vol. 49, No. 3, pp. 417–421. © The Author(s), 2023. This article is an open access publication. Russian Text © The Author(s), 2023, published in Bioorganicheskaya Khimiya, 2023, Vol. 49, No. 3, pp. 224–228. – notice: The Author(s) 2023. ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2023, Vol. 49, No. 3, pp. 417–421. © The Author(s), 2023. This article is an open access publication. Russian Text © The Author(s), 2023, published in Bioorganicheskaya Khimiya, 2023, Vol. 49, No. 3, pp. 224–228. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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In the 1960s and 1970s, the Institute of Chemistry of Natural Compounds developed a topochemical approach for designing new biologically active peptide... Abstract— In the 1960s and 1970s, the Institute of Chemistry of Natural Compounds developed a topochemical approach for designing new biologically active... Abstract—In the 1960s and 1970s, the Institute of Chemistry of Natural Compounds developed a topochemical approach for designing new biologically active... |
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SubjectTerms | Amino acids Binding Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Electric contacts Fluorescence Life Sciences Mollusks Organic Chemistry Peptides Proteins Receptors Residues Review Article Substrate inhibition Toxins Venom toxins |
Title | From Peptides to Receptors |
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