A phase I and pharmacokinetic study of 12-h infusion of flavone acetic acid

• Published in: Cancer chemotherapy and pharmacology Vol. 29; no. 5; p. 354
• Main Authors: Olver, I N, Webster, L K, Bishop, J F, Stokes, K H
• Format: Journal Article
• Language: English
• Published: Germany 1992
• Subjects: Adult; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Antineoplastic Agents - analysis; Antineoplastic Agents - pharmacokinetics; Chromatography, High Pressure Liquid - methods; Dose-Response Relationship, Drug; Drug Evaluation; Flavonoids - administration & dosage; Flavonoids - adverse effects; Flavonoids - analysis; Flavonoids - pharmacokinetics; Humans; Infusions, Intravenous; Neoplasms - drug therapy; Neoplasms - metabolism; Remission Induction; Time Factors

This phase I study investigated flavone acetic acid (FAA) given as a 12-h intravenous infusion every 3 weeks in the absence of urinary alkalinisation. Cohorts of three patients were treated at doses of 7, 10 and 13 g/m2. One subject had colon cancer; 5, renal cancer; and 3, lung cancer. The Eastern...