A single amino acid substitution in the capsid protein VP1 of coxsackievirus B3 (CVB3) alters plaque phenotype in Vero cells but not cardiovirulence in a mouse model

• Published in: Archives of virology Vol. 140; no. 5; p. 959
• Main Authors: Zhang, H, Blake, N W, Ouyang, X, Pandolfino, Y A, Morgan-Capner, P, Archard, L C
• Format: Journal Article
• Language: English
• Published: Austria 01.01.1995
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Capsid - chemistry; Capsid - physiology; Capsid Proteins; Cercopithecus aethiops; Enterovirus B, Human - growth & development; Enterovirus B, Human - pathogenicity; Mice; Molecular Sequence Data; Myocarditis - etiology; Structure-Activity Relationship; Vero Cells; Viral Plaque Assay; Virulence

We previously described a large plaque attenuant (p14V-1) derived from a cardiovirulent Coxsackievirus B3 (CVB3) and showed that there were no major determinants of either attenuation or plaque phenotype in the 5' nontranslated region (5'NTR). Part of the region encoding the last 124 amino...