The roles of cysteines in the heme domain of human soluble guanylate cyclase

• Published in: Chinese chemical letters Vol. 23; no. 8; pp. 973 - 976
• Main Authors: Zhong, Fang Fang, Liu, Xiao Xiao, Pan, Jie, Huang, Zhong Xian, Tan, Xiang Shi
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2012; Department of Chemistry,Fudan University,Shanghai 200433,China%Department of Chemistry,Fudan University,Shanghai 200433,China; Institutes of Biomedical Sciences,Fudan University,Shanghai 200433,China
• Subjects: Cysteine; Dimerization; Heme domain; Human soluble guanylate cyclase; sGC; 二聚化; 凝胶过滤; 半胱氨酸; 可溶性鸟苷酸环化酶; 定向突变; 生物活性; 素域; 血红素; Cysteine; Dimerization; Human soluble guanylate cyclase; sGC; Heme domain

Soluble guanylate cyclase（sGC） is a critical heme-containing enzyme involved in NO signaling.The dimerization of sGC subunits is necessary for its bioactivity and its mechanism is a striking and an indistinct issue.The roles of heme domain cysteines of the sGC on the dimerization and heme binding we...