Synthesis of spherical and rods-like titanium oxide nanoparticles (TiO2 NPs) and evaluation of their cytotoxicity towards colon cells in vitro

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 2; p. 130743
• Main Authors: Klebowski, Bartosz, Kosinska, Karolina, Bukowska, Agnieszka, Zieliński, Piotr M., Parlinska-Wojtan, Magdalena, Depciuch, Joanna
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2025
• Subjects: Cell Line, Tumor; Cell Survival - drug effects; Cellular apoptosis; Cellular uptake; Colon - cytology; Colon - drug effects; Colon - pathology; colon cells; Colonic Neoplasms - drug therapy; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Cytotoxicity; Humans; Metal Nanoparticles - chemistry; Nanoparticles - chemistry; Particle Size; Reactive oxygen species; Reactive Oxygen Species - metabolism; Titanium - chemistry; Titanium - pharmacology; Titanium oxide nanoparticles; Titanium oxide nanoparticles; Cytotoxicity; Reactive oxygen species; Cellular uptake; colon cells; Cellular apoptosis

Titanium oxide nanoparticles (TiO2 NPs) are currently used as ingredients in medicines and sunscreens. Unfortunately, recent information about TiO2 NPs indicates their undesirable biological effect on colon cells. Therefore, the aim of this work was to synthesize and evaluate the physicochemical cha...