The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection

• Published in: Biochimica et biophysica acta. Molecular basis of disease Vol. 1870; no. 5; p. 167193
• Main Authors: Fernández, Jose Javier, Marín, Arturo, Rosales, Romel, Penrice-Randal, Rebekah, Mlcochova, Petra, Alvarez, Yolanda, Villalón-Letelier, Fernando, Yildiz, Soner, Pérez, Enrique, Rathnasinghe, Raveen, Cupic, Anastasija, Kehrer, Thomas, Uccellini, Melissa B., Alonso, Sara, Martínez, Fernando, McGovern, Briana Lynn, Clark, Jordan J., Sharma, Parul, Bayón, Yolanda, Alonso, Andrés, Albrecht, Randy A., White, Kris M., Schotsaert, Michael, Miorin, Lisa, Stewart, James P., Hiscox, Julian A., Gupta, Ravindra K., Irigoyen, Nerea, García-Sastre, Adolfo, Crespo, Mariano Sánchez, Fernández, Nieves
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2024
• Subjects: Animals; COVID-19; COVID-19 - immunology; COVID-19 - metabolism; COVID-19 - pathology; COVID-19 - virology; Cytokines; Cytokines - metabolism; Endoribonucleases - genetics; Endoribonucleases - metabolism; Female; Fluvoxamine; Humans; Mesocricetus; Mice; Mice, Inbred C57BL; Pneumonia; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; SARS-CoV-2 - metabolism; Signal Transduction; TLR; Transcription factors; Unfolded Protein Response; Variants of concern; Viral sepsis; Virus Replication; X-Box Binding Protein 1 - genetics; X-Box Binding Protein 1 - metabolism; COVID-19; Viral sepsis; Pneumonia; Transcription factors; Cytokines; Variants of concern; TLR; Fluvoxamine; Unfolded protein response

SARS-CoV-2 infection can cause severe pneumonia, wherein exacerbated inflammation plays a major role. This is reminiscent of the process commonly termed cytokine storm, a condition dependent on a disproportionated production of cytokines. This state involves the activation of the innate immune respo...