Screening for vitamin D deficiency: a systematic review for the U.S. Preventive Services Task Force
Vitamin D deficiency has been associated with adverse health outcomes. To systematically review benefits and harms of vitamin D screening in asymptomatic adults. Ovid MEDLINE (through the third week of August 2014), Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic...
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Published in | Annals of internal medicine Vol. 162; no. 2; p. 109 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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United States
20.01.2015
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Abstract | Vitamin D deficiency has been associated with adverse health outcomes.
To systematically review benefits and harms of vitamin D screening in asymptomatic adults.
Ovid MEDLINE (through the third week of August 2014), Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews.
Randomized trials of screening for and treatment of vitamin D deficiency and case-control studies nested within the Women's Health Initiative.
One investigator abstracted data, a second reviewed data for accuracy, and 2 investigators independently assessed study quality using predefined criteria.
No study examined the effects of vitamin D screening versus no screening on clinical outcomes. Vitamin D treatment was associated with decreased mortality versus placebo or no treatment (11 studies; risk ratio [RR], 0.83 [95% CI, 0.70 to 0.99]), although benefits were no longer seen after trials of institutionalized persons were excluded (8 studies; RR, 0.93 [CI, 0.73 to 1.18]). Vitamin D treatment was associated with possible decreased risk for having at least 1 fall (5 studies; RR, 0.84 [CI, 0.69 to 1.02]) and falls per person (5 studies; incidence rate ratio, 0.66 [CI, 0.50 to 0.88]) but not fractures (5 studies; RR, 0.98 [CI, 0.82 to 1.16]). Vitamin D treatment was not associated with a statistically significant increased risk for serious adverse events (RR, 1.17 [CI, 0.74 to 1.84]).
Variability across studies in 25-hydroxyvitamin D assays and baseline levels, treatment doses, use of calcium, and duration of follow-up.
Treatment of vitamin D deficiency in asymptomatic persons might reduce mortality risk in institutionalized elderly persons and risk for falls but not fractures.
Agency for Healthcare Research and Quality. |
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AbstractList | Vitamin D deficiency has been associated with adverse health outcomes.
To systematically review benefits and harms of vitamin D screening in asymptomatic adults.
Ovid MEDLINE (through the third week of August 2014), Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews.
Randomized trials of screening for and treatment of vitamin D deficiency and case-control studies nested within the Women's Health Initiative.
One investigator abstracted data, a second reviewed data for accuracy, and 2 investigators independently assessed study quality using predefined criteria.
No study examined the effects of vitamin D screening versus no screening on clinical outcomes. Vitamin D treatment was associated with decreased mortality versus placebo or no treatment (11 studies; risk ratio [RR], 0.83 [95% CI, 0.70 to 0.99]), although benefits were no longer seen after trials of institutionalized persons were excluded (8 studies; RR, 0.93 [CI, 0.73 to 1.18]). Vitamin D treatment was associated with possible decreased risk for having at least 1 fall (5 studies; RR, 0.84 [CI, 0.69 to 1.02]) and falls per person (5 studies; incidence rate ratio, 0.66 [CI, 0.50 to 0.88]) but not fractures (5 studies; RR, 0.98 [CI, 0.82 to 1.16]). Vitamin D treatment was not associated with a statistically significant increased risk for serious adverse events (RR, 1.17 [CI, 0.74 to 1.84]).
Variability across studies in 25-hydroxyvitamin D assays and baseline levels, treatment doses, use of calcium, and duration of follow-up.
Treatment of vitamin D deficiency in asymptomatic persons might reduce mortality risk in institutionalized elderly persons and risk for falls but not fractures.
Agency for Healthcare Research and Quality. |
Author | LeBlanc, Erin S Chou, Roger Zakher, Bernadette Daeges, Monica Pappas, Miranda |
Author_xml | – sequence: 1 givenname: Erin S surname: LeBlanc fullname: LeBlanc, Erin S – sequence: 2 givenname: Bernadette surname: Zakher fullname: Zakher, Bernadette – sequence: 3 givenname: Monica surname: Daeges fullname: Daeges, Monica – sequence: 4 givenname: Miranda surname: Pappas fullname: Pappas, Miranda – sequence: 5 givenname: Roger surname: Chou fullname: Chou, Roger |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25419719$$D View this record in MEDLINE/PubMed |
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Snippet | Vitamin D deficiency has been associated with adverse health outcomes.
To systematically review benefits and harms of vitamin D screening in asymptomatic... |
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SubjectTerms | Accidental Falls - prevention & control Asymptomatic Diseases Calcium - therapeutic use Dietary Supplements Fractures, Bone - prevention & control Homes for the Aged Humans Institutionalization Mass Screening Mortality Risk Assessment Treatment Outcome United States Vitamin D - adverse effects Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D - therapeutic use Vitamin D Deficiency - diagnosis Vitamin D Deficiency - drug therapy |
Title | Screening for vitamin D deficiency: a systematic review for the U.S. Preventive Services Task Force |
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