N6-methyladenosine upregulates ribosome biogenesis in environmental carcinogenesis

• Published in: The Science of the total environment Vol. 881; p. 163428
• Main Authors: Zhao, Tianhe, Sun, Donglei, Long, Keyan, Lemos, Bernardo, Zhang, Qian, Man, Jin, Zhao, Manyu, Zhang, Zunzhen
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 10.07.2023
• Subjects: AKT1; Arsenic; biogenesis; carcinogenesis; Carcinogenicity; cell proliferation; chromium; environment; epigenetics; Heavy metal contaminants; humans; keratinocytes; m6A; microarray technology; multiomics; nickel; ribosomal DNA; Ribosomal proteins; ribosomes; RNA; soil; surface water; m6A; AKT1; Arsenic; Ribosomal proteins; Carcinogenicity; Heavy metal contaminants

Many trace metal pollutants in surface water, the atmosphere, and soil are carcinogenic, and ribosome biogenesis plays an important role in the carcinogenicity of heavy metals. However, the contradiction between upregulated ribosome biogenesis and decreased ribosomal DNA copy number in environmental...