Ascorbic acid-loaded gellan-g-poly(ethylene glycol) methacrylate matrix as a wound-healing material

• Published in: International journal of biological macromolecules Vol. 251; p. 126243
• Main Authors: Ravi, Dharavath, Rajalekshmy, G P, Rekha, M R, Joseph, Roy
• Format: Journal Article
• Language: English
• Published: Netherlands 01.11.2023
• Subjects: Animals; Ascorbic Acid - chemistry; Ascorbic Acid - pharmacology; Fibroblasts - drug effects; Humans; Hydrogels - chemistry; Hydrogels - pharmacology; Keratinocytes - drug effects; Keratinocytes - metabolism; Methacrylates - chemistry; Polyethylene Glycols - chemistry; Polysaccharides, Bacterial - chemistry; Polysaccharides, Bacterial - pharmacology; Wound Healing - drug effects; Gellan gum; Wound care matrix; Poly (ethylene glycol) methacrylate (PEGMA); Ascorbic acid; Wound healing

Ascorbic acid (AA) is one of the important biomolecules involved in all phases of wound healing. The aim of this study was to develop a new hydrogel system that offers topical delivery of ascorbic acid to wounds during wound care management. In this work, we grafted poly (ethylene glycol) methacryla...