A Closed-Loop Control Scheme for Steering Steady States of Glycolysis and Glycogenolysis Pathway

• Published in: IEEE/ACM transactions on computational biology and bioinformatics Vol. 10; no. 4; pp. 858 - 868
• Main Authors: Panja, Surajit, Patra, Sourav, Mukherjee, Anirban, Basu, Madhumita, Sengupta, Sanghamitra, Dutta, Pranab K.
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.07.2013
• Subjects: Biological system modeling; Computational biology; Computational Biology - methods; Computer Simulation; Controllability; Feedback; feedback linearization; glycogenolysis; Glycogenolysis - physiology; glycolysis; Glycolysis - physiology; Linear Models; linear quadratic gaussian regulator; Linearization techniques; Mathematical model; Models, Biological; Nonlinear systems; S-system; Steady-state; Vectors

Biochemical networks normally operate in the neighborhood of one of its multiple steady states. It may reach from one steady state to other within a finite time span. In this paper, a closed-loop control scheme is proposed to steer states of the glycolysis and glycogenolysis (GG) pathway from one of...