Unraveling the synthetic strategy, structure activity relationship of azetidinones: Insights into their multidrug and toxin extrusion protein (MATE transporter) inhibition facilitating drug development against MDR

• Published in: Bioorganic chemistry Vol. 156; p. 108194
• Main Authors: Mal, Suvadeep, Mahapatra, Monalisa, Pakeeraiah, Kakarla, Panda, Preetesh Kumar, Sahoo, Jyotirmaya, Roy, Partha, Paidesetty, Sudhir Kumar
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2025
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Azetidines - chemical synthesis; Azetidines - chemistry; Azetidines - pharmacology; Azetidinone; Cancer; Drug Development; Drug Resistance, Multiple, Bacterial - drug effects; Humans; MATE transporter inhibitor; Microbial; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Multidrug resistance; SAR; Structure-Activity Relationship; β-lactam; MAT; AcOH; SAR; HOMO; LUMO; DABCO; ADMET; EGFR; THF; Rh; IC50; Ph; DMAP; EC50; CA-4; Microbial; DMF; MATE transporter inhibitor; HPLC; nM; CuBr; AcONa; DILI; DCC; MIC; Multidrug resistance; DIPEA; POCl3; LiHMDS; β-lactam; DCM; Naph; LD50; TEA; LC50; ZOI; CuI; ROS; µM; AMPK; Azetidinone; CuCl; IPA; Cancer

[Display omitted] •Chemistry of β-lactams/Azetidinones.•Aspects of different reactions viz., Staudinger’s, Gilman-Speeter, Kinugasa, Ugi-MCR etc. for synthesis of azetidinones.•Schematic representations of various reported azetidinones exploring anticancer and antimicrobial activities.•Structure act...